Inflammation and Immune Response

  1. Cellular Events and Leukocyte Recruitment
    1. Leukocyte Extravasation Process
      1. Margination
        1. Hemodynamic Changes
          1. Cell Size Effects
          2. Rolling
            1. Selectin-Mediated Interactions
              1. P-Selectin
                1. E-Selectin
                  1. L-Selectin
                  2. Selectin Ligands
                  3. Activation
                    1. Chemokine Signaling
                      1. Inside-Out Signaling
                      2. Firm Adhesion
                        1. Integrin-Mediated Binding
                          1. LFA-1
                            1. Mac-1
                              1. VLA-4
                              2. Integrin Ligands
                                1. ICAM-1
                                  1. ICAM-2
                                    1. VCAM-1
                                  2. Transmigration (Diapedesis)
                                    1. Paracellular Migration
                                      1. Transcellular Migration
                                        1. Role of PECAM-1
                                          1. Basement Membrane Crossing
                                        2. Chemotaxis and Migration
                                          1. Chemotactic Factors
                                            1. Bacterial Products
                                              1. Complement Components
                                                1. Chemokines
                                                  1. Lipid Mediators
                                                  2. Chemotactic Mechanisms
                                                    1. Gradient Sensing
                                                      1. Directional Migration
                                                        1. Receptor Desensitization
                                                      2. Leukocyte Activation in Tissues
                                                        1. Phagocytosis
                                                          1. Recognition Mechanisms
                                                            1. Opsonin-Mediated Phagocytosis
                                                              1. Phagosome Formation
                                                                1. Phagolysosome Fusion
                                                                2. Microbial Killing Mechanisms
                                                                  1. Oxygen-Dependent Killing
                                                                    1. Respiratory Burst
                                                                      1. Reactive Oxygen Species
                                                                      2. Oxygen-Independent Killing
                                                                        1. Antimicrobial Peptides
                                                                          1. Enzymes
                                                                            1. Lactoferrin

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                                                                      5. Vascular Events in Acute Inflammation

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                                                                      7. Chemical Mediators of Inflammation