Inflammation and Immune Response

  1. Systemic Effects of Inflammation
    1. Acute Phase Response
      1. Hypothalamic-Pituitary-Adrenal Axis
        1. Fever
          1. Pyrogenic Cytokines
            1. Hypothalamic Temperature Regulation
              1. Prostaglandin E2 Role
                1. Beneficial vs. Harmful Effects
                2. Acute Phase Proteins
                  1. Positive Acute Phase Proteins
                    1. C-Reactive Protein
                      1. Serum Amyloid A
                        1. Fibrinogen
                          1. Complement Components
                          2. Negative Acute Phase Proteins
                            1. Albumin
                              1. Transferrin
                            2. Hematological Changes
                              1. Leukocytosis
                                1. Neutrophilia
                                  1. Left Shift
                                  2. Anemia of Chronic Disease
                                    1. Thrombocytosis
                                    2. Metabolic Changes
                                      1. Protein Catabolism
                                        1. Negative Nitrogen Balance
                                          1. Altered Lipid Metabolism
                                            1. Insulin Resistance
                                          2. Behavioral and Neurological Effects
                                            1. Sickness Behavior
                                              1. Fatigue and Malaise
                                                1. Anorexia
                                                  1. Sleep Disturbances
                                                    1. Cognitive Effects
                                                    2. Cardiovascular Effects
                                                      1. Increased Heart Rate
                                                        1. Altered Blood Pressure
                                                          1. Endothelial Dysfunction
                                                            1. Coagulation Changes
                                                            2. Sepsis and Systemic Inflammatory Response
                                                              1. Systemic Inflammatory Response Syndrome (SIRS)
                                                                1. Sepsis Definition and Criteria
                                                                  1. Severe Sepsis
                                                                    1. Septic Shock
                                                                      1. Multiple Organ Dysfunction Syndrome
                                                                        1. Pathophysiology of Sepsis
                                                                          1. Cytokine Storm
                                                                            1. Complement Activation
                                                                              1. Coagulation Abnormalities
                                                                                1. Endothelial Dysfunction

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                                                                            10. Tissue Repair and Regeneration

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                                                                            12. Regulation of Inflammatory Responses