Inflammation and Immune Response

  1. Tissue Repair and Regeneration
    1. Fundamental Concepts
      1. Regeneration vs. Repair
        1. Tissue Classification by Regenerative Capacity
          1. Labile Tissues
            1. Stable Tissues
              1. Permanent Tissues
            2. Cellular Mechanisms
              1. Cell Cycle Control
                1. Growth Factors and Signaling
                  1. Platelet-Derived Growth Factor (PDGF)
                    1. Fibroblast Growth Factor (FGF)
                      1. Epidermal Growth Factor (EGF)
                        1. Transforming Growth Factor-β (TGF-β)
                        2. Stem Cell Biology
                          1. Embryonic Stem Cells
                            1. Adult Stem Cells
                              1. Induced Pluripotent Stem Cells
                                1. Tissue-Specific Stem Cells
                              2. Extracellular Matrix in Repair
                                1. ECM Components
                                  1. Collagens
                                    1. Elastin
                                      1. Proteoglycans
                                        1. Glycoproteins
                                        2. ECM Functions
                                          1. Structural Support
                                            1. Cell Signaling
                                              1. Growth Factor Sequestration
                                              2. Matrix Remodeling
                                                1. Matrix Metalloproteinases
                                                  1. Tissue Inhibitors of Metalloproteinases
                                                2. Angiogenesis
                                                  1. Mechanisms of Blood Vessel Formation
                                                    1. Angiogenic Factors
                                                      1. Vascular Endothelial Growth Factor (VEGF)
                                                        1. Angiopoietins
                                                          1. Basic FGF
                                                          2. Regulation of Angiogenesis
                                                          3. Wound Healing Process
                                                            1. Hemostasis Phase
                                                              1. Inflammatory Phase
                                                                1. Proliferative Phase
                                                                  1. Remodeling Phase
                                                                  2. Factors Affecting Repair
                                                                    1. Local Factors
                                                                      1. Infection
                                                                        1. Mechanical Stress
                                                                          1. Blood Supply
                                                                            1. Foreign Bodies
                                                                            2. Systemic Factors
                                                                              1. Age
                                                                                1. Nutrition
                                                                                  1. Hormones
                                                                                    1. Systemic Diseases
                                                                                      1. Medications

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                                                                                  9. Chronic Inflammation

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                                                                                  11. Systemic Effects of Inflammation