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Biology
Immunology
Inflammation and Immune Response
1. Introduction to Inflammation and the Immune System
2. Cellular Components of the Immune System
3. Molecular Components and Recognition Systems
4. Initiation and Triggers of Inflammation
5. Vascular Events in Acute Inflammation
6. Cellular Events and Leukocyte Recruitment
7. Chemical Mediators of Inflammation
8. Resolution and Outcomes of Acute Inflammation
9. Chronic Inflammation
10. Tissue Repair and Regeneration
11. Systemic Effects of Inflammation
12. Regulation of Inflammatory Responses
13. Pharmacological Modulation of Inflammation
14. Clinical Assessment and Monitoring
10.
Tissue Repair and Regeneration
10.1.
Fundamental Concepts
10.1.1.
Regeneration vs. Repair
10.1.2.
Tissue Classification by Regenerative Capacity
10.1.2.1.
Labile Tissues
10.1.2.2.
Stable Tissues
10.1.2.3.
Permanent Tissues
10.2.
Cellular Mechanisms
10.2.1.
Cell Cycle Control
10.2.2.
Growth Factors and Signaling
10.2.2.1.
Platelet-Derived Growth Factor (PDGF)
10.2.2.2.
Fibroblast Growth Factor (FGF)
10.2.2.3.
Epidermal Growth Factor (EGF)
10.2.2.4.
Transforming Growth Factor-β (TGF-β)
10.2.3.
Stem Cell Biology
10.2.3.1.
Embryonic Stem Cells
10.2.3.2.
Adult Stem Cells
10.2.3.3.
Induced Pluripotent Stem Cells
10.2.3.4.
Tissue-Specific Stem Cells
10.3.
Extracellular Matrix in Repair
10.3.1.
ECM Components
10.3.1.1.
Collagens
10.3.1.2.
Elastin
10.3.1.3.
Proteoglycans
10.3.1.4.
Glycoproteins
10.3.2.
ECM Functions
10.3.2.1.
Structural Support
10.3.2.2.
Cell Signaling
10.3.2.3.
Growth Factor Sequestration
10.3.3.
Matrix Remodeling
10.3.3.1.
Matrix Metalloproteinases
10.3.3.2.
Tissue Inhibitors of Metalloproteinases
10.4.
Angiogenesis
10.4.1.
Mechanisms of Blood Vessel Formation
10.4.2.
Angiogenic Factors
10.4.2.1.
Vascular Endothelial Growth Factor (VEGF)
10.4.2.2.
Angiopoietins
10.4.2.3.
Basic FGF
10.4.3.
Regulation of Angiogenesis
10.5.
Wound Healing Process
10.5.1.
Hemostasis Phase
10.5.2.
Inflammatory Phase
10.5.3.
Proliferative Phase
10.5.4.
Remodeling Phase
10.6.
Factors Affecting Repair
10.6.1.
Local Factors
10.6.1.1.
Infection
10.6.1.2.
Mechanical Stress
10.6.1.3.
Blood Supply
10.6.1.4.
Foreign Bodies
10.6.2.
Systemic Factors
10.6.2.1.
Age
10.6.2.2.
Nutrition
10.6.2.3.
Hormones
10.6.2.4.
Systemic Diseases
10.6.2.5.
Medications
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11. Systemic Effects of Inflammation