Inflammation and Immune Response

  1. Molecular Components and Recognition Systems
    1. Pattern Recognition Receptors (PRRs)
      1. Toll-like Receptors (TLRs)
        1. TLR Structure and Organization
          1. Individual TLR Specificities
            1. TLR1/TLR2 Heterodimers
              1. TLR3
                1. TLR4
                  1. TLR5
                    1. TLR7/TLR8
                      1. TLR9
                        1. TLR10
                        2. Signaling Pathways
                          1. MyD88-Dependent Pathway
                            1. TRIF-Dependent Pathway
                            2. Cellular Distribution
                            3. NOD-like Receptors (NLRs)
                              1. NOD1 and NOD2
                                1. Inflammasome-Forming NLRs
                                  1. NLRP3
                                    1. NLRC4
                                      1. AIM2
                                      2. Inflammasome Assembly and Activation
                                        1. Caspase-1 Activation
                                          1. IL-1β and IL-18 Processing
                                          2. RIG-I-like Receptors (RLRs)
                                            1. RIG-I
                                              1. MDA5
                                                1. LGP2
                                                  1. Viral RNA Recognition
                                                    1. Type I Interferon Induction
                                                    2. C-type Lectin Receptors
                                                      1. Cytoplasmic DNA Sensors
                                                      2. Antibodies and Immunoglobulins
                                                        1. Basic Antibody Structure
                                                          1. Heavy and Light Chains
                                                            1. Variable and Constant Regions
                                                              1. Antigen-Binding Sites
                                                              2. Antibody Classes
                                                                1. IgG
                                                                  1. Subclasses
                                                                    1. Functions and Distribution
                                                                    2. IgM
                                                                      1. Pentameric Structure
                                                                        1. Primary Immune Response
                                                                        2. IgA
                                                                          1. Secretory IgA
                                                                            1. Mucosal Immunity
                                                                            2. IgE
                                                                              1. Allergic Responses
                                                                                1. Anti-parasitic Functions
                                                                                2. IgD
                                                                                  1. B Cell Receptor Component
                                                                                3. Antibody Functions
                                                                                  1. Neutralization
                                                                                    1. Opsonization
                                                                                      1. Complement Activation
                                                                                        1. Antibody-Dependent Cellular Cytotoxicity (ADCC)
                                                                                      2. Complement System
                                                                                        1. Complement Components
                                                                                          1. Classical Pathway Components
                                                                                            1. Alternative Pathway Components
                                                                                              1. Lectin Pathway Components
                                                                                                1. Terminal Pathway Components
                                                                                                2. Activation Pathways
                                                                                                  1. Classical Pathway
                                                                                                    1. C1 Complex Activation
                                                                                                      1. C4 and C2 Cleavage
                                                                                                      2. Alternative Pathway
                                                                                                        1. C3 Tickover
                                                                                                          1. Properdin Stabilization
                                                                                                          2. Lectin Pathway
                                                                                                            1. Mannose-Binding Lectin
                                                                                                              1. Ficolins
                                                                                                            2. Regulation of Complement
                                                                                                              1. Fluid-Phase Regulators
                                                                                                                1. Membrane-Bound Regulators
                                                                                                                2. Biological Functions
                                                                                                                  1. Opsonization
                                                                                                                    1. Membrane Attack Complex Formation
                                                                                                                      1. Anaphylatoxin Generation
                                                                                                                        1. Immune Complex Clearance

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                                                                                                                    2. Cellular Components of the Immune System

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                                                                                                                    4. Initiation and Triggers of Inflammation