Inflammation and Immune Response

13.

Pharmacological Modulation of Inflammation

13.1.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

13.1.1.

Mechanism of Action

13.1.1.1.

COX-1 Inhibition

13.1.1.2.

COX-2 Inhibition

13.1.2.

13.1.2.1.

Non-Selective NSAIDs

13.1.2.2.

COX-2 Selective Inhibitors

13.1.3.

Therapeutic Effects

13.1.4.

Adverse Effects

13.1.4.1.

Gastrointestinal Toxicity

13.1.4.2.

Cardiovascular Risks

13.1.4.3.

13.2.

Corticosteroids

13.2.1.

Mechanism of Action

13.2.1.1.

Glucocorticoid Receptor Binding

13.2.1.2.

Gene Transcription Effects

13.2.1.3.

Non-Genomic Effects

13.2.2.

Anti-Inflammatory Effects

13.2.3.

Clinical Applications

13.2.4.

13.2.4.1.

Metabolic Effects

13.2.4.2.

Immunosuppression

13.2.4.3.

13.3.

Targeted Biological Therapies

13.3.1.

Anti-TNF Agents

13.3.1.1.

13.3.1.2.

13.3.1.3.

13.3.2.

Anti-IL-1 Therapy

13.3.2.1.

13.3.2.2.

13.3.3.

Anti-IL-6 Therapy

13.3.3.1.

13.3.4.

Other Cytokine Inhibitors

13.4.

13.4.1.

H1 Receptor Antagonists

13.4.2.

H2 Receptor Antagonists

13.4.3.

13.5.

Complement Inhibitors

13.5.1.

C1 Esterase Inhibitor

13.5.2.

Anti-C5 Antibodies

13.6.

Other Anti-Inflammatory Agents

13.6.1.

13.6.2.

13.6.3.

13.6.4.

Hydroxychloroquine

Previous

12. Regulation of Inflammatory Responses

Go to top

Next

14. Clinical Assessment and Monitoring