Clinical Chemistry

  1. Organ System Assessment
    1. Renal Function Tests
      1. Glomerular Function
        1. Blood Urea Nitrogen (BUN)
          1. Synthesis and Excretion
            1. Clinical Significance
              1. Limitations
              2. Serum Creatinine
                1. Production and Excretion
                  1. Clinical Significance
                    1. Limitations
                    2. Creatinine Clearance
                      1. Calculation
                        1. Collection Requirements
                          1. Clinical Significance
                          2. Estimated Glomerular Filtration Rate (eGFR)
                            1. Calculation Methods
                              1. Clinical Utility
                                1. Limitations
                                2. Cystatin C
                                  1. Clinical Utility
                                    1. Advantages over Creatinine
                                  2. Tubular Function
                                    1. Urinalysis
                                      1. Physical Examination
                                        1. Chemical Examination
                                          1. Microscopic Examination
                                          2. Urine Concentration Tests
                                            1. Fractional Excretion of Sodium
                                            2. Proteinuria
                                              1. Types of Proteinuria
                                                1. Microalbuminuria
                                                  1. Protein/Creatinine Ratio
                                                  2. Chronic Kidney Disease
                                                    1. Staging
                                                      1. Laboratory Monitoring
                                                    2. Liver Function Tests
                                                      1. Hepatocellular Injury
                                                        1. Aminotransferases
                                                          1. AST
                                                            1. ALT
                                                              1. AST/ALT Ratio
                                                            2. Cholestatic Injury
                                                              1. Alkaline Phosphatase (ALP)
                                                                1. Isoenzymes
                                                                  1. Clinical Significance
                                                                  2. Gamma-Glutamyl Transferase (GGT)
                                                                    1. Clinical Significance
                                                                    2. 5'-Nucleotidase
                                                                      1. Clinical Significance
                                                                    3. Synthetic Function
                                                                      1. Albumin
                                                                        1. Synthesis
                                                                          1. Clinical Significance
                                                                          2. Prothrombin Time (PT)
                                                                            1. Coagulation Factors
                                                                              1. Clinical Significance
                                                                              2. Cholinesterase
                                                                                1. Clinical Significance
                                                                              3. Bilirubin Metabolism
                                                                                1. Bilirubin
                                                                                  1. Conjugated vs. Unconjugated
                                                                                    1. Clinical Significance
                                                                                    2. Urobilinogen
                                                                                      1. Clinical Significance
                                                                                    3. Liver Disease Patterns
                                                                                      1. Hepatocellular Pattern
                                                                                        1. Cholestatic Pattern
                                                                                          1. Mixed Pattern
                                                                                        2. Cardiac Function Tests
                                                                                          1. Cardiac Enzymes
                                                                                            1. Historical Markers
                                                                                              1. CK-MB
                                                                                                1. LDH
                                                                                                2. Current Markers
                                                                                                  1. Troponins
                                                                                                    1. Myoglobin
                                                                                                  2. Natriuretic Peptides
                                                                                                    1. B-Type Natriuretic Peptide (BNP)
                                                                                                      1. Physiology
                                                                                                        1. Clinical Utility
                                                                                                        2. N-Terminal pro-BNP (NT-proBNP)
                                                                                                          1. Physiology
                                                                                                            1. Clinical Utility
                                                                                                          2. Lipid Risk Factors
                                                                                                            1. Traditional Lipid Panel
                                                                                                              1. Advanced Lipid Testing
                                                                                                              2. Inflammatory Markers
                                                                                                                1. C-Reactive Protein
                                                                                                                  1. Homocysteine
                                                                                                                  2. Acute Coronary Syndromes
                                                                                                                    1. Diagnostic Criteria
                                                                                                                      1. Timing of Markers
                                                                                                                    2. Pancreatic Function Tests
                                                                                                                      1. Exocrine Function
                                                                                                                        1. Amylase
                                                                                                                          1. Pancreatic vs. Salivary
                                                                                                                            1. Clinical Significance
                                                                                                                            2. Lipase
                                                                                                                              1. Clinical Significance
                                                                                                                                1. Specificity
                                                                                                                                2. Elastase
                                                                                                                                  1. Fecal Elastase
                                                                                                                                3. Endocrine Function
                                                                                                                                  1. Glucose Tolerance
                                                                                                                                    1. Oral Glucose Tolerance Test
                                                                                                                                      1. Insulin Response
                                                                                                                                      2. C-Peptide
                                                                                                                                        1. Clinical Utility
                                                                                                                                      3. Pancreatic Disorders
                                                                                                                                        1. Acute Pancreatitis
                                                                                                                                          1. Chronic Pancreatitis
                                                                                                                                            1. Pancreatic Cancer
                                                                                                                                          2. Thyroid Function Panel
                                                                                                                                            1. Primary Tests
                                                                                                                                              1. TSH
                                                                                                                                                1. Clinical Utility
                                                                                                                                                  1. Reference Ranges
                                                                                                                                                  2. Free T4
                                                                                                                                                    1. Clinical Utility
                                                                                                                                                      1. Methods
                                                                                                                                                      2. Free T3
                                                                                                                                                        1. Clinical Utility
                                                                                                                                                          1. When to Order
                                                                                                                                                        2. Secondary Tests
                                                                                                                                                          1. Total T4
                                                                                                                                                            1. Total T3
                                                                                                                                                              1. Reverse T3
                                                                                                                                                                1. Thyroglobulin
                                                                                                                                                                2. Thyroid Antibodies
                                                                                                                                                                  1. Anti-TPO
                                                                                                                                                                    1. Anti-Thyroglobulin
                                                                                                                                                                      1. TSH Receptor Antibodies
                                                                                                                                                                      2. Interpretation Patterns
                                                                                                                                                                        1. Primary Hypothyroidism
                                                                                                                                                                          1. Primary Hyperthyroidism
                                                                                                                                                                            1. Secondary Disorders
                                                                                                                                                                              1. Subclinical Disorders

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