Oncogenes and Cancer

8.

Viral Oncogenes and Cancer

8.1.

Mechanisms of Viral Oncogenesis

8.1.1.

Viral DNA Integration

8.1.2.

Oncoproteins Expression

8.1.3.

Tumor Suppressor Inactivation

8.2.

DNA Tumor Viruses

8.2.1.

Human Papillomavirus

8.2.1.1.

E6 and E7 Oncoproteins

8.2.1.2.

p53 and Rb Inactivation

8.2.1.3.

Cervical Cancer

8.2.1.4.

Other HPV-Associated Cancers

8.2.2.

Epstein-Barr Virus

8.2.2.1.

Latent Membrane Proteins

8.2.2.2.

Burkitt Lymphoma

8.2.2.3.

Nasopharyngeal Carcinoma

8.2.2.4.

Hodgkin Lymphoma

8.2.3.

Hepatitis B Virus

8.2.3.1.

8.2.3.2.

Chronic Infection

8.2.3.3.

Hepatocellular Carcinoma

8.2.4.

8.2.4.1.

E1A and E1B Proteins

8.2.4.2.

Transformation Mechanisms

8.2.5.

8.2.5.1.

Large T Antigen

8.2.5.2.

Small t Antigen

8.3.

RNA Tumor Viruses

8.3.1.

Human T-lymphotropic Virus 1

8.3.1.1.

8.3.1.2.

Adult T-cell Leukemia

8.3.2.

Hepatitis C Virus

8.3.2.1.

Chronic Infection

8.3.2.2.

Liver Cancer Development

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7. Tumor Suppressor Genes

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9. Multi-Step Carcinogenesis