Oncogenes and Cancer

  1. Oncogene Discovery and Research Methods
    1. Historical Approaches
      1. Retroviral Studies
        1. DNA Transfection Assays
          1. Chromosome Analysis
          2. Modern Genomic Approaches
            1. Cancer Genome Sequencing
              1. Whole Exome Sequencing
                1. Whole Genome Sequencing
                  1. RNA Sequencing
                  2. Large-Scale Cancer Genomics Projects
                    1. The Cancer Genome Atlas
                      1. International Cancer Genome Consortium
                        1. Pediatric Cancer Genome Project
                        2. Functional Validation Methods
                          1. Cell Culture Assays
                            1. Transformation Assays
                              1. Animal Models
                                1. CRISPR/Cas9 Systems
                                2. Bioinformatics Tools
                                  1. Mutation Analysis Software
                                    1. Pathway Analysis
                                      1. Database Resources

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                                    9. Multi-Step Carcinogenesis

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                                    11. Therapeutic Targeting of Oncogenes