Oncogenes and Cancer

  1. Tumor Suppressor Genes
    1. Basic Concepts
      1. Definition and Function
        1. Growth Inhibitory Roles
          1. Genomic Stability Maintenance
          2. Two-Hit Hypothesis
            1. Knudson's Model
              1. Loss of Heterozygosity
                1. Haploinsufficiency
                2. Recessive Nature of Mutations
                  1. Contrast with Oncogenes
                    1. Inheritance Patterns
                    2. Major Tumor Suppressors
                      1. TP53
                        1. Guardian of the Genome
                          1. DNA Damage Response
                            1. Cell Cycle Arrest
                              1. Apoptosis Induction
                                1. p53 Mutations in Cancer
                                2. RB1
                                  1. G1/S Checkpoint Control
                                    1. E2F Regulation
                                      1. Retinoblastoma Syndrome
                                      2. BRCA1 and BRCA2
                                        1. Homologous Recombination
                                          1. DNA Repair Functions
                                            1. Hereditary Breast Cancer
                                            2. PTEN
                                              1. PI3K/AKT Pathway Regulation
                                                1. Phosphatase Activity
                                                  1. Cowden Syndrome
                                                  2. APC
                                                    1. Wnt Signaling Regulation
                                                      1. Familial Adenomatous Polyposis
                                                        1. Colorectal Cancer
                                                        2. NF1
                                                          1. Ras Regulation
                                                            1. Neurofibromatosis Type 1
                                                            2. VHL
                                                              1. HIF Regulation
                                                                1. Von Hippel-Lindau Syndrome

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                                                            6. Major Oncogene Families

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                                                            8. Viral Oncogenes and Cancer