Oncogenes and Cancer

  1. Proto-Oncogenes: Normal Cellular Functions
    1. Definition and Basic Concepts
      1. Role in Normal Cell Growth
        1. Role in Cell Division
          1. Role in Cell Differentiation
          2. Functional Classification
            1. Growth Factors
              1. Platelet-Derived Growth Factor
                1. Epidermal Growth Factor
                  1. Fibroblast Growth Factors
                  2. Growth Factor Receptors
                    1. Receptor Tyrosine Kinases
                      1. G-Protein Coupled Receptors
                        1. Cytokine Receptors
                        2. Intracellular Signal Transducers
                          1. G-Proteins
                            1. Ras Family
                              1. Rho Family
                              2. Protein Kinases
                                1. Serine/Threonine Kinases
                                  1. Tyrosine Kinases
                                  2. Phosphatases
                                  3. Transcription Factors
                                    1. Regulation of Gene Expression
                                      1. Control of Cell Fate Decisions
                                        1. DNA-Binding Domains
                                        2. Cell Cycle Regulators
                                          1. Cyclins
                                            1. Cyclin-Dependent Kinases
                                            2. Apoptosis Regulators
                                              1. Bcl-2 Family
                                                1. Caspases
                                                  1. p53 Pathway Components

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                                              3. Apoptosis and Cell Death Mechanisms

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                                              5. Oncogene Activation Mechanisms