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Biology
Genetics and Genomics
Oncogenes and Cancer
1. Introduction to Cancer Biology
2. Normal Cell Cycle Regulation
3. Apoptosis and Cell Death Mechanisms
4. Proto-Oncogenes: Normal Cellular Functions
5. Oncogene Activation Mechanisms
6. Major Oncogene Families
7. Tumor Suppressor Genes
8. Viral Oncogenes and Cancer
9. Multi-Step Carcinogenesis
10. Oncogene Discovery and Research Methods
11. Therapeutic Targeting of Oncogenes
12. Clinical Applications and Future Directions
4.
Proto-Oncogenes: Normal Cellular Functions
4.1.
Definition and Basic Concepts
4.1.1.
Role in Normal Cell Growth
4.1.2.
Role in Cell Division
4.1.3.
Role in Cell Differentiation
4.2.
Functional Classification
4.2.1.
Growth Factors
4.2.1.1.
Platelet-Derived Growth Factor
4.2.1.2.
Epidermal Growth Factor
4.2.1.3.
Fibroblast Growth Factors
4.2.2.
Growth Factor Receptors
4.2.2.1.
Receptor Tyrosine Kinases
4.2.2.2.
G-Protein Coupled Receptors
4.2.2.3.
Cytokine Receptors
4.2.3.
Intracellular Signal Transducers
4.2.3.1.
G-Proteins
4.2.3.1.1.
Ras Family
4.2.3.1.2.
Rho Family
4.2.3.2.
Protein Kinases
4.2.3.2.1.
Serine/Threonine Kinases
4.2.3.2.2.
Tyrosine Kinases
4.2.3.3.
Phosphatases
4.2.4.
Transcription Factors
4.2.4.1.
Regulation of Gene Expression
4.2.4.2.
Control of Cell Fate Decisions
4.2.4.3.
DNA-Binding Domains
4.2.5.
Cell Cycle Regulators
4.2.5.1.
Cyclins
4.2.5.2.
Cyclin-Dependent Kinases
4.2.6.
Apoptosis Regulators
4.2.6.1.
Bcl-2 Family
4.2.6.2.
Caspases
4.2.6.3.
p53 Pathway Components
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3. Apoptosis and Cell Death Mechanisms
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5. Oncogene Activation Mechanisms