Neurology

  1. Muscle Diseases
    1. Normal Muscle Structure and Function
      1. Muscle Fiber Types
        1. Contractile Proteins
          1. Energy Metabolism
            1. Excitation-Contraction Coupling
            2. Classification of Myopathies
              1. Inherited Myopathies
                1. Acquired Myopathies
                  1. Inflammatory Myopathies
                    1. Metabolic Myopathies
                      1. Toxic Myopathies
                      2. Muscular Dystrophies
                        1. Dystrophinopathies
                          1. Duchenne Muscular Dystrophy
                            1. Genetics
                              1. Dystrophin Gene
                                1. X-Linked Inheritance
                                  1. Mutations
                                  2. Pathophysiology
                                    1. Dystrophin Function
                                      1. Membrane Instability
                                        1. Muscle Degeneration
                                        2. Clinical Features
                                          1. Early Onset
                                            1. Progressive Weakness
                                              1. Pseudohypertrophy
                                                1. Gowers' Sign
                                                  1. Cardiac Involvement
                                                    1. Respiratory Involvement
                                                      1. Cognitive Impairment
                                                      2. Diagnosis
                                                        1. Clinical Criteria
                                                          1. Creatine Kinase
                                                            1. Genetic Testing
                                                              1. Muscle Biopsy
                                                                1. Immunohistochemistry
                                                                2. Management
                                                                  1. Corticosteroids
                                                                    1. Cardiac Monitoring
                                                                      1. Respiratory Support
                                                                        1. Physical Therapy
                                                                          1. Orthopedic Management
                                                                            1. Emerging Therapies
                                                                              1. Exon Skipping
                                                                                1. Gene Therapy
                                                                                  1. Utrophin Upregulation
                                                                              2. Becker Muscular Dystrophy
                                                                                1. Genetics
                                                                                  1. Pathophysiology
                                                                                    1. Clinical Features
                                                                                      1. Diagnosis
                                                                                        1. Management
                                                                                      2. Limb-Girdle Muscular Dystrophies
                                                                                        1. LGMD1 (Autosomal Dominant)
                                                                                          1. LGMD2 (Autosomal Recessive)
                                                                                            1. Clinical Features
                                                                                              1. Diagnosis
                                                                                                1. Management
                                                                                                2. Facioscapulohumeral Dystrophy
                                                                                                  1. Genetics
                                                                                                    1. D4Z4 Repeat Contraction
                                                                                                      1. DUX4 Expression
                                                                                                      2. Clinical Features
                                                                                                        1. Facial Weakness
                                                                                                          1. Scapular Winging
                                                                                                            1. Asymmetric Weakness
                                                                                                            2. Diagnosis
                                                                                                              1. Management
                                                                                                              2. Myotonic Dystrophies
                                                                                                                1. Myotonic Dystrophy Type 1
                                                                                                                  1. Genetics
                                                                                                                    1. DMPK Gene
                                                                                                                      1. CTG Repeat Expansion
                                                                                                                      2. Pathophysiology
                                                                                                                        1. RNA Toxicity
                                                                                                                          1. Splicing Defects
                                                                                                                          2. Clinical Features
                                                                                                                            1. Myotonia
                                                                                                                              1. Distal Weakness
                                                                                                                                1. Multisystem Involvement
                                                                                                                                  1. Cardiac Conduction Defects
                                                                                                                                    1. Cataracts
                                                                                                                                      1. Endocrine Abnormalities
                                                                                                                                        1. Cognitive Impairment
                                                                                                                                      2. Diagnosis
                                                                                                                                        1. Management
                                                                                                                                        2. Myotonic Dystrophy Type 2
                                                                                                                                          1. Genetics
                                                                                                                                            1. Clinical Features
                                                                                                                                              1. Diagnosis
                                                                                                                                                1. Management
                                                                                                                                              2. Emery-Dreifuss Muscular Dystrophy
                                                                                                                                                1. Genetics
                                                                                                                                                  1. Clinical Features
                                                                                                                                                    1. Diagnosis
                                                                                                                                                      1. Management
                                                                                                                                                      2. Oculopharyngeal Muscular Dystrophy
                                                                                                                                                        1. Genetics
                                                                                                                                                          1. Clinical Features
                                                                                                                                                            1. Diagnosis
                                                                                                                                                              1. Management
                                                                                                                                                            2. Congenital Myopathies
                                                                                                                                                              1. Central Core Disease
                                                                                                                                                                1. Genetics
                                                                                                                                                                  1. Pathology
                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                      1. Management
                                                                                                                                                                      2. Nemaline Myopathy
                                                                                                                                                                        1. Genetics
                                                                                                                                                                          1. Pathology
                                                                                                                                                                            1. Clinical Features
                                                                                                                                                                              1. Management
                                                                                                                                                                              2. Centronuclear Myopathy
                                                                                                                                                                                1. Genetics
                                                                                                                                                                                  1. Pathology
                                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                                      1. Management
                                                                                                                                                                                      2. Multi-Minicore Disease
                                                                                                                                                                                        1. Genetics
                                                                                                                                                                                          1. Pathology
                                                                                                                                                                                            1. Clinical Features
                                                                                                                                                                                              1. Management
                                                                                                                                                                                            2. Inflammatory Myopathies
                                                                                                                                                                                              1. Dermatomyositis
                                                                                                                                                                                                1. Pathophysiology
                                                                                                                                                                                                  1. Complement-Mediated Vasculopathy
                                                                                                                                                                                                    1. Type I Interferon Pathway
                                                                                                                                                                                                    2. Clinical Features
                                                                                                                                                                                                      1. Skin Manifestations
                                                                                                                                                                                                        1. Heliotrope Rash
                                                                                                                                                                                                          1. Gottron's Papules
                                                                                                                                                                                                            1. Shawl Sign
                                                                                                                                                                                                              1. V-Sign
                                                                                                                                                                                                              2. Muscle Weakness
                                                                                                                                                                                                                1. Extramuscular Manifestations
                                                                                                                                                                                                                  1. Interstitial Lung Disease
                                                                                                                                                                                                                    1. Cardiac Involvement
                                                                                                                                                                                                                      1. Malignancy Association
                                                                                                                                                                                                                    2. Diagnosis
                                                                                                                                                                                                                      1. Clinical Criteria
                                                                                                                                                                                                                        1. Laboratory Tests
                                                                                                                                                                                                                          1. Muscle Enzymes
                                                                                                                                                                                                                            1. Autoantibodies
                                                                                                                                                                                                                            2. Muscle Biopsy
                                                                                                                                                                                                                              1. Imaging
                                                                                                                                                                                                                              2. Management
                                                                                                                                                                                                                                1. Corticosteroids
                                                                                                                                                                                                                                  1. Immunosuppressive Agents
                                                                                                                                                                                                                                    1. IVIG
                                                                                                                                                                                                                                      1. Supportive Care
                                                                                                                                                                                                                                    2. Polymyositis
                                                                                                                                                                                                                                      1. Pathophysiology
                                                                                                                                                                                                                                        1. T-Cell Mediated
                                                                                                                                                                                                                                          1. Endomysial Inflammation
                                                                                                                                                                                                                                          2. Clinical Features
                                                                                                                                                                                                                                            1. Proximal Weakness
                                                                                                                                                                                                                                              1. Muscle Pain
                                                                                                                                                                                                                                                1. Extramuscular Features
                                                                                                                                                                                                                                                2. Diagnosis
                                                                                                                                                                                                                                                  1. Clinical Criteria
                                                                                                                                                                                                                                                    1. Laboratory Tests
                                                                                                                                                                                                                                                      1. Muscle Biopsy
                                                                                                                                                                                                                                                      2. Management
                                                                                                                                                                                                                                                        1. Corticosteroids
                                                                                                                                                                                                                                                          1. Immunosuppressive Agents
                                                                                                                                                                                                                                                        2. Inclusion Body Myositis
                                                                                                                                                                                                                                                          1. Pathophysiology
                                                                                                                                                                                                                                                            1. Degenerative and Inflammatory
                                                                                                                                                                                                                                                              1. Protein Aggregation
                                                                                                                                                                                                                                                              2. Clinical Features
                                                                                                                                                                                                                                                                1. Asymmetric Weakness
                                                                                                                                                                                                                                                                  1. Distal Involvement
                                                                                                                                                                                                                                                                    1. Finger Flexor Weakness
                                                                                                                                                                                                                                                                      1. Quadriceps Weakness
                                                                                                                                                                                                                                                                      2. Diagnosis
                                                                                                                                                                                                                                                                        1. Clinical Criteria
                                                                                                                                                                                                                                                                          1. Muscle Biopsy
                                                                                                                                                                                                                                                                            1. Characteristic Inclusions
                                                                                                                                                                                                                                                                            2. Management
                                                                                                                                                                                                                                                                              1. Limited Response to Treatment
                                                                                                                                                                                                                                                                                1. Supportive Care
                                                                                                                                                                                                                                                                              2. Necrotizing Myopathy
                                                                                                                                                                                                                                                                                1. Immune-Mediated Necrotizing Myopathy
                                                                                                                                                                                                                                                                                  1. Statin-Associated Myopathy
                                                                                                                                                                                                                                                                                    1. Anti-SRP Myopathy
                                                                                                                                                                                                                                                                                      1. Anti-HMGCR Myopathy
                                                                                                                                                                                                                                                                                        1. Clinical Features
                                                                                                                                                                                                                                                                                          1. Diagnosis
                                                                                                                                                                                                                                                                                            1. Management
                                                                                                                                                                                                                                                                                          2. Metabolic Myopathies
                                                                                                                                                                                                                                                                                            1. Glycogen Storage Diseases
                                                                                                                                                                                                                                                                                              1. Pompe Disease (GSD II)
                                                                                                                                                                                                                                                                                                1. Genetics
                                                                                                                                                                                                                                                                                                  1. Pathophysiology
                                                                                                                                                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                                                                                                                                                      1. Infantile Form
                                                                                                                                                                                                                                                                                                        1. Late-Onset Form
                                                                                                                                                                                                                                                                                                        2. Diagnosis
                                                                                                                                                                                                                                                                                                          1. Management
                                                                                                                                                                                                                                                                                                            1. Enzyme Replacement Therapy
                                                                                                                                                                                                                                                                                                          2. McArdle Disease (GSD V)
                                                                                                                                                                                                                                                                                                            1. Genetics
                                                                                                                                                                                                                                                                                                              1. Clinical Features
                                                                                                                                                                                                                                                                                                                1. Diagnosis
                                                                                                                                                                                                                                                                                                                  1. Management
                                                                                                                                                                                                                                                                                                                  2. Phosphofructokinase Deficiency (GSD VII)
                                                                                                                                                                                                                                                                                                                    1. Other Glycogen Storage Diseases
                                                                                                                                                                                                                                                                                                                    2. Lipid Storage Myopathies
                                                                                                                                                                                                                                                                                                                      1. Carnitine Palmitoyltransferase II Deficiency
                                                                                                                                                                                                                                                                                                                        1. Genetics
                                                                                                                                                                                                                                                                                                                          1. Clinical Features
                                                                                                                                                                                                                                                                                                                            1. Diagnosis
                                                                                                                                                                                                                                                                                                                              1. Management
                                                                                                                                                                                                                                                                                                                              2. Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
                                                                                                                                                                                                                                                                                                                                1. Other Lipid Storage Disorders
                                                                                                                                                                                                                                                                                                                                2. Mitochondrial Myopathies
                                                                                                                                                                                                                                                                                                                                  1. Mitochondrial DNA Mutations
                                                                                                                                                                                                                                                                                                                                    1. Nuclear DNA Mutations
                                                                                                                                                                                                                                                                                                                                      1. Clinical Features
                                                                                                                                                                                                                                                                                                                                        1. Exercise Intolerance
                                                                                                                                                                                                                                                                                                                                          1. Muscle Weakness
                                                                                                                                                                                                                                                                                                                                            1. Multisystem Involvement
                                                                                                                                                                                                                                                                                                                                            2. Diagnosis
                                                                                                                                                                                                                                                                                                                                              1. Muscle Biopsy
                                                                                                                                                                                                                                                                                                                                                1. Genetic Testing
                                                                                                                                                                                                                                                                                                                                                  1. Biochemical Studies
                                                                                                                                                                                                                                                                                                                                                  2. Management
                                                                                                                                                                                                                                                                                                                                                    1. Supportive Care
                                                                                                                                                                                                                                                                                                                                                      1. Coenzyme Q10
                                                                                                                                                                                                                                                                                                                                                        1. Exercise Training
                                                                                                                                                                                                                                                                                                                                                    2. Endocrine Myopathies
                                                                                                                                                                                                                                                                                                                                                      1. Thyroid Myopathy
                                                                                                                                                                                                                                                                                                                                                        1. Hyperthyroid Myopathy
                                                                                                                                                                                                                                                                                                                                                          1. Hypothyroid Myopathy
                                                                                                                                                                                                                                                                                                                                                            1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                              1. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                1. Management
                                                                                                                                                                                                                                                                                                                                                                2. Steroid Myopathy
                                                                                                                                                                                                                                                                                                                                                                  1. Cushing's Syndrome
                                                                                                                                                                                                                                                                                                                                                                    1. Exogenous Steroids
                                                                                                                                                                                                                                                                                                                                                                      1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                        1. Management
                                                                                                                                                                                                                                                                                                                                                                        2. Other Endocrine Myopathies
                                                                                                                                                                                                                                                                                                                                                                          1. Hyperparathyroidism
                                                                                                                                                                                                                                                                                                                                                                            1. Hypoparathyroidism
                                                                                                                                                                                                                                                                                                                                                                              1. Adrenal Insufficiency
                                                                                                                                                                                                                                                                                                                                                                            2. Toxic Myopathies
                                                                                                                                                                                                                                                                                                                                                                              1. Drug-Induced Myopathies
                                                                                                                                                                                                                                                                                                                                                                                1. Statins
                                                                                                                                                                                                                                                                                                                                                                                  1. Colchicine
                                                                                                                                                                                                                                                                                                                                                                                    1. Chloroquine
                                                                                                                                                                                                                                                                                                                                                                                      1. Zidovudine
                                                                                                                                                                                                                                                                                                                                                                                        1. Corticosteroids
                                                                                                                                                                                                                                                                                                                                                                                        2. Other Toxic Myopathies
                                                                                                                                                                                                                                                                                                                                                                                        3. Rhabdomyolysis
                                                                                                                                                                                                                                                                                                                                                                                          1. Etiology
                                                                                                                                                                                                                                                                                                                                                                                            1. Traumatic Causes
                                                                                                                                                                                                                                                                                                                                                                                              1. Non-Traumatic Causes
                                                                                                                                                                                                                                                                                                                                                                                                1. Drug-Induced
                                                                                                                                                                                                                                                                                                                                                                                                  1. Metabolic Causes
                                                                                                                                                                                                                                                                                                                                                                                                  2. Pathophysiology
                                                                                                                                                                                                                                                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                                                                                                                                                                                                                                                      1. Diagnosis
                                                                                                                                                                                                                                                                                                                                                                                                        1. Creatine Kinase
                                                                                                                                                                                                                                                                                                                                                                                                          1. Myoglobinuria
                                                                                                                                                                                                                                                                                                                                                                                                            1. Electrolyte Abnormalities
                                                                                                                                                                                                                                                                                                                                                                                                            2. Management
                                                                                                                                                                                                                                                                                                                                                                                                              1. Fluid Resuscitation
                                                                                                                                                                                                                                                                                                                                                                                                                1. Alkalinization
                                                                                                                                                                                                                                                                                                                                                                                                                  1. Monitoring
                                                                                                                                                                                                                                                                                                                                                                                                                    1. Complications Management

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                                                                                                                                                                                                                                                                                                                                                                                                                15. Spinal Cord Disorders