Neurology

  1. Neuromuscular Junction Disorders
    1. Normal Neuromuscular Transmission
      1. Anatomy of the Neuromuscular Junction
        1. Presynaptic Terminal
          1. Synaptic Cleft
            1. Postsynaptic Membrane
            2. Physiology of Neuromuscular Transmission
              1. Acetylcholine Synthesis
                1. Vesicle Release
                  1. Receptor Binding
                    1. Muscle Contraction
                      1. Acetylcholine Degradation
                      2. Safety Factor
                      3. Myasthenia Gravis
                        1. Epidemiology
                          1. Incidence and Prevalence
                            1. Age and Gender Distribution
                              1. Geographic Variations
                              2. Pathophysiology
                                1. Autoimmune Mechanism
                                  1. Acetylcholine Receptor Antibodies
                                    1. MuSK Antibodies
                                      1. LRP4 Antibodies
                                        1. Seronegative Myasthenia Gravis
                                          1. Thymic Abnormalities
                                          2. Clinical Features
                                            1. Fluctuating Weakness
                                              1. Fatigability
                                                1. Ocular Symptoms
                                                  1. Ptosis
                                                    1. Diplopia
                                                    2. Bulbar Symptoms
                                                      1. Dysarthria
                                                        1. Dysphagia
                                                          1. Chewing Difficulty
                                                          2. Limb Weakness
                                                            1. Respiratory Symptoms
                                                            2. Classification
                                                              1. Ocular Myasthenia Gravis
                                                                1. Generalized Myasthenia Gravis
                                                                  1. MGFA Classification
                                                                  2. Diagnosis
                                                                    1. Clinical Assessment
                                                                      1. Pharmacological Tests
                                                                        1. Edrophonium Test
                                                                          1. Ice Pack Test
                                                                          2. Serological Tests
                                                                            1. AChR Antibodies
                                                                              1. MuSK Antibodies
                                                                                1. LRP4 Antibodies
                                                                                2. Electrophysiological Tests
                                                                                  1. Repetitive Nerve Stimulation
                                                                                    1. Single-Fiber EMG
                                                                                    2. Imaging
                                                                                      1. Chest CT/MRI
                                                                                    3. Management
                                                                                      1. Symptomatic Treatment
                                                                                        1. Cholinesterase Inhibitors
                                                                                          1. Pyridostigmine
                                                                                            1. Neostigmine
                                                                                          2. Immunosuppressive Therapy
                                                                                            1. Corticosteroids
                                                                                              1. Azathioprine
                                                                                                1. Mycophenolate Mofetil
                                                                                                  1. Methotrexate
                                                                                                    1. Cyclosporine
                                                                                                      1. Tacrolimus
                                                                                                      2. Acute Treatment
                                                                                                        1. Plasma Exchange
                                                                                                          1. Intravenous Immunoglobulin
                                                                                                          2. Thymectomy
                                                                                                            1. Indications
                                                                                                              1. Surgical Approaches
                                                                                                                1. Outcomes
                                                                                                                2. Emerging Therapies
                                                                                                                  1. Rituximab
                                                                                                                    1. Eculizumab
                                                                                                                      1. Efgartigimod
                                                                                                                    2. Myasthenic Crisis
                                                                                                                      1. Precipitating Factors
                                                                                                                        1. Clinical Features
                                                                                                                          1. Management
                                                                                                                            1. Respiratory Support
                                                                                                                              1. Immunotherapy
                                                                                                                                1. Supportive Care
                                                                                                                              2. Drug-Induced Myasthenia
                                                                                                                                1. Penicillamine
                                                                                                                                  1. Interferon
                                                                                                                                    1. Checkpoint Inhibitors
                                                                                                                                  2. Lambert-Eaton Myasthenic Syndrome
                                                                                                                                    1. Epidemiology
                                                                                                                                      1. Pathophysiology
                                                                                                                                        1. Voltage-Gated Calcium Channel Antibodies
                                                                                                                                          1. Presynaptic Dysfunction
                                                                                                                                            1. Associated Malignancies
                                                                                                                                            2. Clinical Features
                                                                                                                                              1. Proximal Weakness
                                                                                                                                                1. Autonomic Symptoms
                                                                                                                                                  1. Facilitation
                                                                                                                                                    1. Ocular Sparing
                                                                                                                                                    2. Diagnosis
                                                                                                                                                      1. Clinical Criteria
                                                                                                                                                        1. Electrophysiological Tests
                                                                                                                                                          1. Repetitive Nerve Stimulation
                                                                                                                                                            1. Post-Exercise Facilitation
                                                                                                                                                            2. Serological Tests
                                                                                                                                                              1. VGCC Antibodies
                                                                                                                                                              2. Malignancy Screening
                                                                                                                                                              3. Management
                                                                                                                                                                1. Symptomatic Treatment
                                                                                                                                                                  1. 3,4-Diaminopyridine
                                                                                                                                                                    1. Pyridostigmine
                                                                                                                                                                    2. Immunosuppressive Therapy
                                                                                                                                                                      1. Cancer Treatment
                                                                                                                                                                    3. Congenital Myasthenic Syndromes
                                                                                                                                                                      1. Classification
                                                                                                                                                                        1. Presynaptic CMS
                                                                                                                                                                          1. Synaptic CMS
                                                                                                                                                                            1. Postsynaptic CMS
                                                                                                                                                                            2. Genetics
                                                                                                                                                                              1. CHAT Mutations
                                                                                                                                                                                1. COLQ Mutations
                                                                                                                                                                                  1. CHRNE Mutations
                                                                                                                                                                                    1. DOK7 Mutations
                                                                                                                                                                                      1. Other Genetic Causes
                                                                                                                                                                                      2. Clinical Features
                                                                                                                                                                                        1. Early Onset
                                                                                                                                                                                          1. Fluctuating Weakness
                                                                                                                                                                                            1. Respiratory Symptoms
                                                                                                                                                                                            2. Diagnosis
                                                                                                                                                                                              1. Genetic Testing
                                                                                                                                                                                                1. Electrophysiological Studies
                                                                                                                                                                                                  1. Family History
                                                                                                                                                                                                  2. Management
                                                                                                                                                                                                    1. Cholinesterase Inhibitors
                                                                                                                                                                                                      1. 3,4-Diaminopyridine
                                                                                                                                                                                                        1. Ephedrine
                                                                                                                                                                                                          1. Salbutamol
                                                                                                                                                                                                        2. Botulism
                                                                                                                                                                                                          1. Etiology
                                                                                                                                                                                                            1. Clostridium botulinum
                                                                                                                                                                                                              1. Botulinum Toxin Types
                                                                                                                                                                                                              2. Types of Botulism
                                                                                                                                                                                                                1. Foodborne Botulism
                                                                                                                                                                                                                  1. Wound Botulism
                                                                                                                                                                                                                    1. Infant Botulism
                                                                                                                                                                                                                      1. Iatrogenic Botulism
                                                                                                                                                                                                                        1. Inhalational Botulism
                                                                                                                                                                                                                        2. Pathophysiology
                                                                                                                                                                                                                          1. Toxin Mechanism
                                                                                                                                                                                                                            1. SNARE Protein Cleavage
                                                                                                                                                                                                                              1. Acetylcholine Release Blockade
                                                                                                                                                                                                                              2. Clinical Features
                                                                                                                                                                                                                                1. Descending Paralysis
                                                                                                                                                                                                                                  1. Cranial Nerve Involvement
                                                                                                                                                                                                                                    1. Autonomic Symptoms
                                                                                                                                                                                                                                      1. Respiratory Failure
                                                                                                                                                                                                                                      2. Diagnosis
                                                                                                                                                                                                                                        1. Clinical Criteria
                                                                                                                                                                                                                                          1. Laboratory Tests
                                                                                                                                                                                                                                            1. Toxin Detection
                                                                                                                                                                                                                                              1. Culture
                                                                                                                                                                                                                                              2. Electrophysiological Studies
                                                                                                                                                                                                                                              3. Management
                                                                                                                                                                                                                                                1. Supportive Care
                                                                                                                                                                                                                                                  1. Antitoxin
                                                                                                                                                                                                                                                    1. Antibiotics (Wound Botulism)
                                                                                                                                                                                                                                                      1. Respiratory Support
                                                                                                                                                                                                                                                      2. Prevention
                                                                                                                                                                                                                                                      3. Other Neuromuscular Junction Disorders
                                                                                                                                                                                                                                                        1. Organophosphate Poisoning
                                                                                                                                                                                                                                                          1. Mechanism
                                                                                                                                                                                                                                                            1. Clinical Features
                                                                                                                                                                                                                                                              1. Diagnosis
                                                                                                                                                                                                                                                                1. Management
                                                                                                                                                                                                                                                                2. Snake Bite Envenomation
                                                                                                                                                                                                                                                                  1. Neurotoxic Snakes
                                                                                                                                                                                                                                                                    1. Clinical Features
                                                                                                                                                                                                                                                                      1. Management
                                                                                                                                                                                                                                                                      2. Tick Paralysis
                                                                                                                                                                                                                                                                        1. Mechanism
                                                                                                                                                                                                                                                                          1. Clinical Features
                                                                                                                                                                                                                                                                            1. Management
                                                                                                                                                                                                                                                                            2. Hypermagnesemia
                                                                                                                                                                                                                                                                              1. Mechanism
                                                                                                                                                                                                                                                                                1. Clinical Features
                                                                                                                                                                                                                                                                                  1. Management

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                                                                                                                                                                                                                                                                              12. Disorders of the Peripheral Nervous System

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                                                                                                                                                                                                                                                                              14. Muscle Diseases