Molecular Biology

  1. Gene Regulation
    1. Principles of Gene Regulation
      1. Levels of Control
        1. Regulatory Elements
          1. Transcription Factors
            1. Regulatory Networks
            2. Prokaryotic Gene Regulation
              1. Operon Structure
                1. Lac Operon
                  1. Operon Components
                    1. Negative Control
                      1. Positive Control
                        1. Catabolite Repression
                        2. Trp Operon
                          1. Operon Components
                            1. Repressor Function
                              1. Attenuation Mechanism
                              2. Other Regulatory Systems
                                1. ara Operon
                                  1. mal Operon
                                    1. Two-component Systems
                                  2. Eukaryotic Gene Regulation
                                    1. Chromatin Structure
                                      1. Nucleosome Organization
                                        1. Histone Modifications
                                          1. Acetylation
                                            1. Methylation
                                              1. Phosphorylation
                                                1. Ubiquitination
                                                2. DNA Methylation
                                                  1. CpG Islands
                                                    1. Methylation Patterns
                                                      1. Gene Silencing
                                                      2. Chromatin Remodeling
                                                        1. SWI/SNF Complex
                                                          1. ISWI Complex
                                                            1. CHD Complex
                                                          2. Transcriptional Control
                                                            1. Promoter Elements
                                                              1. Enhancers and Silencers
                                                                1. Transcription Factors
                                                                  1. DNA-binding Domains
                                                                    1. Activation Domains
                                                                      1. Repression Domains
                                                                      2. Mediator Complex
                                                                        1. Insulators
                                                                        2. Post-transcriptional Control
                                                                          1. Alternative Splicing Regulation
                                                                            1. mRNA Stability
                                                                              1. AU-rich Elements
                                                                                1. microRNA Regulation
                                                                                2. RNA Interference
                                                                                  1. miRNA Pathway
                                                                                    1. siRNA Pathway
                                                                                      1. RISC Complex
                                                                                    2. Translational Control
                                                                                      1. 5' UTR Regulation
                                                                                        1. Upstream Open Reading Frames
                                                                                          1. Internal Ribosome Entry Sites
                                                                                            1. microRNA-mediated Repression
                                                                                            2. Post-translational Control
                                                                                              1. Protein Modifications
                                                                                                1. Protein Degradation
                                                                                                  1. Subcellular Localization

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                                                                                              7. Translation

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                                                                                              9. Genome Organization and Structure