Molecular Biology

  1. Protein Structure and Function
    1. Amino Acids
      1. General Structure
        1. Alpha Carbon
          1. Amino Group
            1. Carboxyl Group
              1. Side Chain Variability
              2. Classification by Properties
                1. Nonpolar Amino Acids
                  1. Hydrophobic Characteristics
                    1. Structural Roles
                    2. Polar Uncharged Amino Acids
                      1. Hydrogen Bonding Capacity
                        1. Functional Groups
                        2. Charged Amino Acids
                          1. Acidic Amino Acids
                            1. Basic Amino Acids
                              1. Ionic Interactions
                            2. Special Amino Acids
                              1. Proline
                                1. Glycine
                                  1. Cysteine
                                2. Protein Structure Hierarchy
                                  1. Primary Structure
                                    1. Peptide Bond Formation
                                      1. Amino Acid Sequence
                                        1. Sequence Determination
                                        2. Secondary Structure
                                          1. Alpha Helix
                                            1. Hydrogen Bonding Pattern
                                              1. Geometric Parameters
                                                1. Amino Acid Preferences
                                                2. Beta Sheet
                                                  1. Parallel Arrangement
                                                    1. Antiparallel Arrangement
                                                      1. Hydrogen Bonding
                                                      2. Beta Turns
                                                        1. Random Coil
                                                        2. Tertiary Structure
                                                          1. Folding Forces
                                                            1. Hydrophobic Interactions
                                                              1. Hydrogen Bonds
                                                                1. Electrostatic Interactions
                                                                  1. Disulfide Bonds
                                                                  2. Protein Domains
                                                                    1. Structural Motifs
                                                                    2. Quaternary Structure
                                                                      1. Subunit Assembly
                                                                        1. Protein Complexes
                                                                          1. Allosteric Regulation
                                                                        2. Protein Folding
                                                                          1. Folding Pathways
                                                                            1. Molecular Chaperones
                                                                              1. Heat Shock Proteins
                                                                                1. Chaperonins
                                                                                  1. Protein Disulfide Isomerases
                                                                                  2. Protein Misfolding
                                                                                    1. Aggregation
                                                                                      1. Amyloid Formation
                                                                                        1. Disease Implications
                                                                                      2. Protein Function
                                                                                        1. Enzyme Catalysis
                                                                                          1. Structural Proteins
                                                                                            1. Transport Proteins
                                                                                              1. Regulatory Proteins
                                                                                                1. Defense Proteins

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                                                                                              3. Structure of Nucleic Acids

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                                                                                              5. DNA Replication