Molecular Biology

10.

DNA Damage and Repair

10.1.

Types of DNA Damage

10.1.1.

Spontaneous Damage

10.1.1.1.

Hydrolytic Damage

10.1.1.2.

Oxidative Damage

10.1.1.3.

Replication Errors

10.1.2.

10.1.2.1.

Chemical Mutagens

10.1.2.2.

Radiation Damage

10.1.2.3.

Cross-linking Agents

10.2.

10.2.1.

Point Mutations

10.2.1.1.

10.2.1.2.

10.2.1.3.

Silent Mutations

10.2.1.4.

Missense Mutations

10.2.1.5.

Nonsense Mutations

10.2.2.

Insertion and Deletion Mutations

10.2.2.1.

Frameshift Mutations

10.2.2.2.

In-frame Mutations

10.2.3.

Chromosomal Mutations

10.2.3.1.

10.2.3.2.

10.2.3.3.

10.2.3.4.

10.3.

DNA Repair Mechanisms

10.3.1.

10.3.1.1.

10.3.1.2.

Alkyltransferases

10.3.2.

Base Excision Repair

10.3.2.1.

DNA Glycosylases

10.3.2.2.

AP Endonuclease

10.3.2.3.

10.3.2.4.

10.3.3.

Nucleotide Excision Repair

10.3.3.1.

Damage Recognition

10.3.3.2.

10.3.3.3.

10.3.3.4.

Repair Synthesis

10.3.4.

Mismatch Repair

10.3.4.1.

Mismatch Recognition

10.3.4.2.

10.3.4.3.

10.3.5.

Double-strand Break Repair

10.3.5.1.

Homologous Recombination

10.3.5.1.1.

Strand Invasion

10.3.5.1.2.

Holiday Junction Formation

10.3.5.1.3.

10.3.5.2.

Non-homologous End Joining

10.3.5.2.1.

10.3.5.2.2.

10.3.6.

Recombinational Repair

10.3.7.

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