Molecular Biology

  1. DNA Damage and Repair
    1. Types of DNA Damage
      1. Spontaneous Damage
        1. Hydrolytic Damage
          1. Oxidative Damage
            1. Replication Errors
            2. Induced Damage
              1. Chemical Mutagens
                1. Radiation Damage
                  1. Cross-linking Agents
                2. Mutation Types
                  1. Point Mutations
                    1. Transitions
                      1. Transversions
                        1. Silent Mutations
                          1. Missense Mutations
                            1. Nonsense Mutations
                            2. Insertion and Deletion Mutations
                              1. Frameshift Mutations
                                1. In-frame Mutations
                                2. Chromosomal Mutations
                                  1. Deletions
                                    1. Duplications
                                      1. Inversions
                                        1. Translocations
                                      2. DNA Repair Mechanisms
                                        1. Direct Repair
                                          1. Photolyase
                                            1. Alkyltransferases
                                            2. Base Excision Repair
                                              1. DNA Glycosylases
                                                1. AP Endonuclease
                                                  1. DNA Polymerase
                                                    1. DNA Ligase
                                                    2. Nucleotide Excision Repair
                                                      1. Damage Recognition
                                                        1. Incision
                                                          1. Excision
                                                            1. Repair Synthesis
                                                            2. Mismatch Repair
                                                              1. Mismatch Recognition
                                                                1. Excision
                                                                  1. Resynthesis
                                                                  2. Double-strand Break Repair
                                                                    1. Homologous Recombination
                                                                      1. Strand Invasion
                                                                        1. Holiday Junction Formation
                                                                          1. Resolution
                                                                          2. Non-homologous End Joining
                                                                            1. End Processing
                                                                              1. Ligation
                                                                            2. Recombinational Repair
                                                                              1. SOS Response

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                                                                            9. Genome Organization and Structure

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                                                                            11. Molecular Biology Techniques