Muscle Physiology

  1. Muscle Relaxation
    1. Cessation of Neural Stimulation
      1. Action Potential Termination
        1. Membrane Repolarization
        2. Calcium Removal
          1. Sarcoplasmic Reticulum Calcium Pumps
            1. SERCA Function
              1. ATP Requirements
                1. Pump Regulation
                2. Calcium Sequestration
                  1. Calsequestrin Binding
                  2. Regulatory Protein Reset
                    1. Calcium Dissociation from Troponin C
                      1. Troponin Complex Return
                        1. Tropomyosin Repositioning
                          1. Actin Site Blocking
                          2. Cross-bridge Detachment
                            1. Loss of Myosin-Actin Interaction
                              1. Return to Resting State
                              2. Muscle Length Restoration
                                1. Elastic Recoil
                                  1. Passive Stretching Forces
                                    1. Titin Function
                                    2. Energy Requirements for Relaxation
                                      1. ATP for Calcium Pumping
                                        1. Metabolic Cost

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                                      6. The Sliding Filament Mechanism

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                                      8. Mechanics of Muscle Contraction