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Biology
Anatomy and Physiology
Muscle Physiology
1. Introduction to Muscle Tissue
2. Skeletal Muscle Anatomy
3. The Sarcomere
4. The Neuromuscular Junction
5. Excitation-Contraction Coupling
6. The Sliding Filament Mechanism
7. Muscle Relaxation
8. Mechanics of Muscle Contraction
9. Muscle Metabolism and Energetics
10. Muscle Fatigue
11. Muscle Fiber Types
12. Exercise Adaptations
13. Smooth Muscle Physiology
14. Cardiac Muscle Physiology
10.
Muscle Fatigue
10.1.
Definition of Muscle Fatigue
10.1.1.
Performance Decline
10.1.2.
Force Reduction
10.1.3.
Fatigue vs Weakness
10.2.
Central Fatigue
10.2.1.
Neural Drive Reduction
10.2.2.
Motivation and Perception
10.2.3.
Neurotransmitter Changes
10.2.4.
Central Command Failure
10.3.
Peripheral Fatigue
10.3.1.
Metabolic Factors
10.3.1.1.
ATP Depletion
10.3.1.2.
Phosphocreatine Depletion
10.3.1.3.
Glycogen Depletion
10.3.2.
Metabolite Accumulation
10.3.2.1.
Lactate and pH
10.3.2.2.
Inorganic Phosphate
10.3.2.3.
Potassium Accumulation
10.3.3.
Excitation-Contraction Coupling Failure
10.3.3.1.
Calcium Release Impairment
10.3.3.2.
Calcium Reuptake Problems
10.3.3.3.
T-tubule Function
10.3.4.
Cross-bridge Function Impairment
10.4.
Fatigue Mechanisms by Fiber Type
10.4.1.
Type I Fiber Fatigue
10.4.2.
Type II Fiber Fatigue
10.4.3.
Differential Susceptibility
10.5.
Recovery from Fatigue
10.5.1.
Metabolite Clearance
10.5.2.
Energy Store Replenishment
10.5.3.
Ion Balance Restoration
10.5.4.
Time Course of Recovery
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9. Muscle Metabolism and Energetics
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11. Muscle Fiber Types