Muscle Physiology

  1. Muscle Fatigue
    1. Definition of Muscle Fatigue
      1. Performance Decline
        1. Force Reduction
          1. Fatigue vs Weakness
          2. Central Fatigue
            1. Neural Drive Reduction
              1. Motivation and Perception
                1. Neurotransmitter Changes
                  1. Central Command Failure
                  2. Peripheral Fatigue
                    1. Metabolic Factors
                      1. ATP Depletion
                        1. Phosphocreatine Depletion
                          1. Glycogen Depletion
                          2. Metabolite Accumulation
                            1. Lactate and pH
                              1. Inorganic Phosphate
                                1. Potassium Accumulation
                                2. Excitation-Contraction Coupling Failure
                                  1. Calcium Release Impairment
                                    1. Calcium Reuptake Problems
                                      1. T-tubule Function
                                      2. Cross-bridge Function Impairment
                                      3. Fatigue Mechanisms by Fiber Type
                                        1. Type I Fiber Fatigue
                                          1. Type II Fiber Fatigue
                                            1. Differential Susceptibility
                                            2. Recovery from Fatigue
                                              1. Metabolite Clearance
                                                1. Energy Store Replenishment
                                                  1. Ion Balance Restoration
                                                    1. Time Course of Recovery

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                                                  9. Muscle Metabolism and Energetics

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                                                  11. Muscle Fiber Types