Muscle Physiology

  1. The Sliding Filament Mechanism
    1. Sliding Filament Theory
      1. Historical Development
        1. Evidence Supporting Theory
          1. Fundamental Principles
          2. Cross-bridge Cycle
            1. ATP Hydrolysis Phase
              1. Myosin ATPase Activity
                1. Energy Storage
                  1. Myosin Head Cocking
                  2. Cross-bridge Formation
                    1. Myosin-Actin Binding
                      1. Strong Binding State
                        1. Rigor Complex
                        2. Power Stroke
                          1. Conformational Change
                            1. Force Generation
                              1. Filament Sliding
                                1. ADP and Pi Release
                                2. Cross-bridge Detachment
                                  1. ATP Binding
                                    1. Myosin-Actin Dissociation
                                      1. Cycle Reset
                                      2. Cycle Repetition
                                        1. Continuous Cycling
                                          1. Calcium Dependence
                                        2. Molecular Mechanics
                                          1. Force Generation Mechanisms
                                            1. Lever Arm Movement
                                              1. Elastic Elements
                                                1. Work and Power Output
                                                2. Regulation of Cross-bridge Cycling
                                                  1. Calcium Availability
                                                    1. ATP Concentration
                                                      1. pH Effects
                                                        1. Temperature Effects
                                                        2. Sarcomere Length Changes
                                                          1. I Band Shortening
                                                            1. H Zone Reduction
                                                              1. A Band Constancy
                                                                1. Overall Muscle Shortening

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                                                              5. Excitation-Contraction Coupling

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                                                              7. Muscle Relaxation