Muscle Physiology

  1. The Sarcomere
    1. Organization of the Sarcomere
      1. Repeating Units
        1. Alignment in Myofibrils
          1. Boundaries and Dimensions
          2. Thick Filaments
            1. Myosin Protein Structure
              1. Heavy Chains
                1. Light Chains
                  1. Molecular Structure
                  2. Myosin Heads
                    1. Cross-bridge Structure
                      1. Binding Sites
                        1. Conformational States
                        2. ATPase Activity
                          1. Enzymatic Properties
                            1. Regulation
                            2. Arrangement in Sarcomere
                            3. Thin Filaments
                              1. Actin Protein Structure
                                1. G-actin Monomers
                                  1. F-actin Polymers
                                    1. Binding Sites
                                    2. Tropomyosin
                                      1. Structure and Function
                                        1. Position on Actin
                                          1. Regulatory Role
                                          2. Troponin Complex
                                            1. Troponin C
                                              1. Calcium Binding Sites
                                                1. Conformational Changes
                                                2. Troponin I
                                                  1. Inhibitory Function
                                                    1. Actin Binding
                                                    2. Troponin T
                                                      1. Tropomyosin Binding
                                                        1. Structural Role
                                                    3. Structural Proteins
                                                      1. Titin
                                                        1. Molecular Structure
                                                          1. Elasticity Properties
                                                            1. Stability Function
                                                              1. Role in Passive Tension
                                                              2. Nebulin
                                                                1. Structure and Location
                                                                  1. Regulation of Thin Filament Length
                                                                    1. Actin Binding
                                                                    2. Dystrophin
                                                                      1. Connection to Sarcolemma
                                                                        1. Structural Support
                                                                          1. Clinical Relevance
                                                                          2. Other Structural Proteins
                                                                            1. Alpha-actinin
                                                                              1. Myomesin
                                                                                1. C-protein
                                                                              2. Sarcomere Bands and Lines
                                                                                1. A Band
                                                                                  1. Composition
                                                                                    1. Appearance
                                                                                      1. Length Changes
                                                                                      2. I Band
                                                                                        1. Composition
                                                                                          1. Appearance
                                                                                            1. Length Changes
                                                                                            2. H Zone
                                                                                              1. Composition
                                                                                                1. Appearance
                                                                                                  1. Length Changes
                                                                                                  2. M Line
                                                                                                    1. Composition
                                                                                                      1. Function
                                                                                                      2. Z Disc
                                                                                                        1. Composition
                                                                                                          1. Function
                                                                                                            1. Protein Interactions
                                                                                                            2. Changes During Contraction
                                                                                                              1. Band Length Alterations
                                                                                                                1. Filament Overlap

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                                                                                                            2. Skeletal Muscle Anatomy

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                                                                                                            4. The Neuromuscular Junction