Muscle Physiology

  1. Excitation-Contraction Coupling
    1. Overview of Excitation-Contraction Coupling
      1. Importance in Muscle Function
        1. Sequence of Events
        2. Action Potential Propagation
          1. Sarcolemma Depolarization
            1. T-tubule Invasion
              1. Electrical Signal Transmission
              2. Voltage Sensing
                1. Dihydropyridine Receptors
                  1. Structure and Location
                    1. Voltage Sensing Function
                      1. L-type Calcium Channels
                      2. Conformational Changes
                        1. Mechanical Coupling
                        2. Calcium Release
                          1. Ryanodine Receptors
                            1. Structure and Location
                              1. Calcium Release Channels
                                1. Regulation
                                2. Calcium-induced Calcium Release
                                  1. Sarcoplasmic Reticulum Calcium Stores
                                  2. Calcium Binding and Regulation
                                    1. Troponin C Calcium Binding
                                      1. Conformational Changes
                                        1. Cooperative Binding
                                        2. Regulatory Protein Changes
                                          1. Troponin Complex Movement
                                            1. Tropomyosin Displacement
                                              1. Actin Site Exposure
                                              2. Cross-bridge Formation Initiation
                                                1. Myosin Binding Site Availability
                                                  1. Initial Cross-bridge Attachment

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                                                4. The Neuromuscular Junction

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                                                6. The Sliding Filament Mechanism