Microbiology

  1. Immune System Function
    1. Innate Immunity
      1. First Line Defenses
        1. Physical Barriers
          1. Skin Integrity
            1. Mucous Membranes
              1. Ciliary Action
              2. Chemical Barriers
                1. Antimicrobial Secretions
                  1. pH Barriers
                    1. Antimicrobial Peptides
                    2. Normal Microbiota
                      1. Competitive Exclusion
                        1. Colonization Resistance
                      2. Second Line Defenses
                        1. Cellular Components
                          1. Neutrophils
                            1. Macrophages
                              1. Dendritic Cells
                                1. Natural Killer Cells
                                2. Phagocytosis
                                  1. Recognition
                                    1. Engulfment
                                      1. Phagolysosome Formation
                                        1. Microbial Killing
                                        2. Inflammation
                                          1. Vascular Changes
                                            1. Cellular Recruitment
                                              1. Inflammatory Mediators
                                                1. Resolution
                                                2. Fever Response
                                                  1. Pyrogen Action
                                                    1. Temperature Elevation
                                                      1. Metabolic Effects
                                                      2. Complement System
                                                        1. Classical Pathway
                                                          1. Alternative Pathway
                                                            1. Lectin Pathway
                                                              1. Complement Functions
                                                              2. Interferons
                                                                1. Type I Interferons
                                                                  1. Antiviral Activity
                                                                    1. Immune Modulation
                                                                2. Adaptive Immunity
                                                                  1. Immune Recognition
                                                                    1. Antigens
                                                                      1. Antigen Structure
                                                                        1. Epitopes
                                                                          1. Antigenicity vs. Immunogenicity
                                                                          2. Major Histocompatibility Complex
                                                                            1. MHC Class I
                                                                              1. MHC Class II
                                                                                1. Antigen Presentation
                                                                              2. Humoral Immunity
                                                                                1. B Cell Development
                                                                                  1. B Cell Activation
                                                                                    1. Antibody Structure
                                                                                      1. Heavy and Light Chains
                                                                                        1. Variable and Constant Regions
                                                                                          1. Antibody Classes
                                                                                          2. Antibody Functions
                                                                                            1. Neutralization
                                                                                              1. Opsonization
                                                                                                1. Complement Activation
                                                                                                  1. Antibody-Dependent Cellular Cytotoxicity
                                                                                                2. Cell-Mediated Immunity
                                                                                                  1. T Cell Development
                                                                                                    1. T Cell Types
                                                                                                      1. Helper T Cells
                                                                                                        1. Cytotoxic T Cells
                                                                                                          1. Regulatory T Cells
                                                                                                          2. T Cell Activation
                                                                                                            1. Effector Functions
                                                                                                              1. Cytokine Production
                                                                                                                1. Cell-Mediated Cytotoxicity
                                                                                                                  1. Immune Regulation
                                                                                                                2. Immunological Memory
                                                                                                                  1. Memory Cell Formation
                                                                                                                    1. Primary vs. Secondary Response
                                                                                                                      1. Vaccination Principles
                                                                                                                        1. Long-Term Protection

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                                                                                                                    14. Pathogenicity Mechanisms

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                                                                                                                    16. Antimicrobial Therapy