Microbiology

  1. Pathogenicity Mechanisms
    1. Pathogen Entry
      1. Portal of Entry
        1. Respiratory Tract
          1. Gastrointestinal Tract
            1. Genitourinary Tract
              1. Skin Penetration
                1. Parenteral Introduction
                2. Infectious Dose
                  1. ID50 Concept
                    1. Dose-Response Relationships
                      1. Host Susceptibility Factors
                    2. Adhesion and Colonization
                      1. Adhesion Mechanisms
                        1. Adhesins
                          1. Receptor Binding
                            1. Biofilm Formation
                            2. Colonization Factors
                              1. Nutrient Competition
                                1. pH Tolerance
                                  1. Antimicrobial Resistance
                                2. Invasion and Spread
                                  1. Tissue Invasion
                                    1. Invasins
                                      1. Cell Entry Mechanisms
                                        1. Intracellular Survival
                                        2. Immune Evasion
                                          1. Capsule Formation
                                            1. Antigenic Variation
                                              1. Immune Suppression
                                                1. Molecular Mimicry
                                                2. Spreading Factors
                                                  1. Hyaluronidase
                                                    1. Collagenase
                                                      1. Kinases
                                                        1. Coagulases
                                                      2. Tissue Damage
                                                        1. Direct Damage
                                                          1. Cell Lysis
                                                            1. Metabolic Disruption
                                                              1. Nutrient Depletion
                                                              2. Toxin Production
                                                                1. Exotoxins
                                                                  1. Neurotoxins
                                                                    1. Enterotoxins
                                                                      1. Cytotoxins
                                                                        1. Superantigens
                                                                        2. Endotoxins
                                                                          1. Lipopolysaccharide
                                                                            1. Systemic Effects
                                                                              1. Septic Shock
                                                                            2. Host Response Damage
                                                                              1. Inflammatory Response
                                                                                1. Immune Complex Formation
                                                                                  1. Autoimmune Reactions
                                                                                2. Pathogen Exit
                                                                                  1. Portal of Exit
                                                                                    1. Respiratory Secretions
                                                                                      1. Fecal Excretion
                                                                                        1. Urogenital Discharge
                                                                                          1. Blood and Body Fluids
                                                                                          2. Transmission Facilitation
                                                                                            1. Coughing and Sneezing
                                                                                              1. Diarrhea Production
                                                                                                1. Vector Attraction

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                                                                                            13. Disease Principles and Epidemiology

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                                                                                            15. Immune System Function