Iron Transport and Receptors in Bacteria

  1. Iron Homeostasis Regulation
    1. Fur Regulatory System
      1. Fur Protein Structure
        1. DNA-binding Domain
          1. Metal-binding Sites
            1. Dimerization Interface
            2. Mechanism of Repression
              1. Fe²⁺-dependent DNA Binding
                1. Fur Box Recognition
                  1. Transcriptional Control
                  2. Fur Regulon
                    1. Iron Uptake Genes
                      1. Siderophore Biosynthesis
                        1. Storage Proteins
                          1. Oxidative Stress Genes
                        2. Small RNA Regulation
                          1. RyhB sRNA
                            1. Fur-dependent Expression
                              1. Target mRNA Recognition
                                1. Hfq-mediated Interactions
                                2. Other Iron-responsive sRNAs
                                  1. PrrF1/PrrF2 in Pseudomonas
                                    1. NrrF in Neisseria
                                      1. Species-specific Variants
                                      2. Post-transcriptional Mechanisms
                                        1. mRNA Stability Control
                                          1. Translation Inhibition
                                            1. Ribosome Binding Site Occlusion
                                          2. Additional Regulatory Networks
                                            1. Two-component Systems
                                              1. PmrA/PmrB System
                                                1. Integration with Iron Sensing
                                                  1. Environmental Response
                                                  2. Sigma Factor Regulation
                                                    1. Alternative Sigma Factors
                                                      1. Stress Response Integration
                                                        1. Iron-dependent Promoters
                                                        2. Quorum Sensing Integration
                                                          1. Population Density Signals
                                                            1. Siderophore Production Control
                                                              1. Virulence Coordination

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                                                          7. Intracellular Iron Processing

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                                                          9. Iron Acquisition and Bacterial Pathogenesis