Iron Transport and Receptors in Bacteria

  1. Therapeutic Applications and Drug Development
    1. Antimicrobial Strategies
      1. Siderophore-Antibiotic Conjugates
        1. Trojan Horse Approach
          1. Cefiderocol Example
            1. Mechanism of Action
              1. Clinical Development
              2. Biosynthesis Inhibition
                1. NRPS Inhibitors
                  1. Enzyme Target Identification
                    1. Structure-based Design
                    2. Transport System Targeting
                      1. Receptor Antagonists
                        1. Transport Inhibitors
                          1. Competitive Inhibition
                        2. Vaccine Development
                          1. Outer Membrane Receptor Antigens
                            1. Immunogenicity Studies
                              1. Protective Efficacy
                                1. Cross-strain Protection
                                2. Siderophore-based Vaccines
                                  1. Hapten-carrier Conjugates
                                    1. Immune Response Induction
                                      1. Passive Immunization
                                    2. Biotechnological Applications
                                      1. Bioremediation
                                        1. Heavy Metal Chelation
                                          1. Soil Decontamination
                                            1. Environmental Cleanup
                                            2. Agricultural Applications
                                              1. Plant Growth Promotion
                                                1. Iron Biofortification
                                                  1. Biocontrol Agents
                                                  2. Industrial Applications
                                                    1. Metal Recovery Processes
                                                      1. Biosensor Development
                                                        1. Biotechnology Tools

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                                                    9. Iron Acquisition and Bacterial Pathogenesis

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                                                    1. Iron in Bacterial Physiology