Iron Transport and Receptors in Bacteria

  1. Iron Bioavailability Challenges
    1. Chemical Constraints
      1. Ferric Iron Precipitation
        1. Hydrolysis at Neutral pH
          1. Formation of Insoluble Hydroxides
          2. Oxygen-mediated Oxidation
            1. Fe²⁺ to Fe³⁺ Conversion
              1. Kinetics in Aerobic Environments
            2. Host Iron Sequestration
              1. Nutritional Immunity Concept
                1. Evolutionary Basis
                  1. Host Defense Strategy
                  2. Extracellular Iron-binding Proteins
                    1. Transferrin
                      1. Structure and Iron-binding Sites
                        1. Serum Concentration
                          1. Receptor-mediated Uptake by Host Cells
                          2. Lactoferrin
                            1. Distribution in Body Secretions
                              1. Antimicrobial Properties
                                1. Iron-withholding Function
                              2. Intracellular Iron Storage
                                1. Ferritin
                                  1. Protein Shell Structure
                                    1. Iron Core Formation
                                      1. Regulated Iron Release
                                      2. Hemosiderin
                                        1. Iron Storage in Macrophages
                                          1. Pathological Iron Accumulation
                                        2. Heme-bound Iron
                                          1. Hemoglobin Structure
                                            1. Myoglobin Distribution
                                              1. Heme Accessibility to Pathogens

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                                          1. Iron in Bacterial Physiology

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                                          3. Bacterial Iron Acquisition Strategies