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Biology
Microbiology
Iron Transport and Receptors in Bacteria
1. Iron in Bacterial Physiology
2. Iron Bioavailability Challenges
3. Bacterial Iron Acquisition Strategies
4. Siderophore Structure and Function
5. Outer Membrane Iron Receptors
6. Periplasmic and Inner Membrane Transport
7. Intracellular Iron Processing
8. Iron Homeostasis Regulation
9. Iron Acquisition and Bacterial Pathogenesis
10. Therapeutic Applications and Drug Development
6.
Periplasmic and Inner Membrane Transport
6.1.
Periplasmic Binding Proteins
6.1.1.
Structural Features
6.1.1.1.
Two-domain Architecture
6.1.1.2.
Ligand-binding Cleft
6.1.1.3.
Conformational Changes
6.1.2.
Substrate Specificity
6.1.2.1.
Iron-siderophore Recognition
6.1.2.2.
Binding Affinity
6.1.2.3.
Transport Kinetics
6.1.3.
Representative Examples
6.1.3.1.
FepB (Enterobactin-binding)
6.1.3.2.
FhuD (Ferrichrome-binding)
6.1.3.3.
IutD (Aerobactin-binding)
6.2.
ABC Transporter Systems
6.2.1.
General Architecture
6.2.1.1.
Periplasmic Binding Protein
6.2.1.2.
Transmembrane Domains
6.2.1.3.
Nucleotide-binding Domains
6.2.2.
Transport Mechanism
6.2.2.1.
ATP Hydrolysis Cycle
6.2.2.2.
Conformational Switching
6.2.2.3.
Substrate Translocation
6.2.3.
Specific Transport Systems
6.2.3.1.
Fep System (Enterobactin)
6.2.3.2.
Fhu System (Ferrichrome)
6.2.3.3.
Iut System (Aerobactin)
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5. Outer Membrane Iron Receptors
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7. Intracellular Iron Processing