Iron Transport and Receptors in Bacteria

  1. Periplasmic and Inner Membrane Transport
    1. Periplasmic Binding Proteins
      1. Structural Features
        1. Two-domain Architecture
          1. Ligand-binding Cleft
            1. Conformational Changes
            2. Substrate Specificity
              1. Iron-siderophore Recognition
                1. Binding Affinity
                  1. Transport Kinetics
                  2. Representative Examples
                    1. FepB (Enterobactin-binding)
                      1. FhuD (Ferrichrome-binding)
                        1. IutD (Aerobactin-binding)
                      2. ABC Transporter Systems
                        1. General Architecture
                          1. Periplasmic Binding Protein
                            1. Transmembrane Domains
                              1. Nucleotide-binding Domains
                              2. Transport Mechanism
                                1. ATP Hydrolysis Cycle
                                  1. Conformational Switching
                                    1. Substrate Translocation
                                    2. Specific Transport Systems
                                      1. Fep System (Enterobactin)
                                        1. Fhu System (Ferrichrome)
                                          1. Iut System (Aerobactin)

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                                      5. Outer Membrane Iron Receptors

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                                      7. Intracellular Iron Processing