Iron Transport and Receptors in Bacteria

  1. Outer Membrane Iron Receptors
    1. TonB-dependent Transporter Architecture
      1. β-barrel Structure
        1. 22-strand Antiparallel β-barrel
          1. Extracellular Loops
            1. Periplasmic Turns
            2. Plug Domain
              1. N-terminal Globular Domain
                1. TonB Box Motifs
                  1. Gating Mechanism
                  2. Substrate Binding Sites
                    1. Extracellular Recognition
                      1. Conformational Changes
                    2. Energy Transduction System
                      1. TonB Protein
                        1. Periplasmic Localization
                          1. C-terminal Domain Structure
                            1. Interaction with Plug Domain
                            2. ExbB Protein
                              1. Inner Membrane Anchor
                                1. Proton Channel Formation
                                  1. Oligomeric Assembly
                                  2. ExbD Protein
                                    1. Inner Membrane Component
                                      1. Interaction with ExbB
                                        1. Energy Coupling Function
                                        2. Proton Motive Force Utilization
                                          1. Energetics of Transport
                                            1. Conformational Coupling
                                              1. Transport Cycle
                                            2. Receptor Diversity and Specificity
                                              1. Ligand Recognition Mechanisms
                                                1. Binding Site Architecture
                                                  1. Specificity Determinants
                                                    1. Induced Fit Mechanisms
                                                    2. Siderophore Piracy
                                                      1. Cross-recognition Phenomena
                                                        1. Evolutionary Advantages
                                                          1. Ecological Implications
                                                        2. Major Receptor Examples
                                                          1. FepA
                                                            1. Enterobactin Recognition
                                                              1. Structural Studies
                                                                1. Transport Mechanism
                                                                2. FhuA
                                                                  1. Ferrichrome Specificity
                                                                    1. Phage Receptor Function
                                                                      1. Antibiotic Uptake
                                                                      2. IutA
                                                                        1. Aerobactin Transport
                                                                          1. Virulence Association
                                                                            1. Regulation Patterns
                                                                            2. FyuA
                                                                              1. Yersiniabactin Uptake
                                                                                1. Pathogenicity Role
                                                                                  1. Distribution in Enterobacteria

                                                                              Previous

                                                                              4. Siderophore Structure and Function

                                                                              Go to top

                                                                              Next

                                                                              6. Periplasmic and Inner Membrane Transport