Cell Signaling and Signal Transduction

Cell signaling and signal transduction encompass the complex communication system that allows cells to perceive and respond to their microenvironment and to communicate with each other. This process begins when an extracellular signaling molecule, such as a hormone or growth factor, binds to a specific receptor on a target cell's surface or within its cytoplasm. This binding event triggers signal transduction, a cascade of intracellular molecular events that converts, amplifies, and relays the external signal to various effector proteins, ultimately culminating in a specific cellular response, such as a change in gene expression, metabolism, cell shape, or motility, which is fundamental for development, tissue repair, and homeostasis in multicellular organisms.

  1. Fundamentals of Cell Communication
    1. General Principles of Signaling
      1. Definition of Cell Signaling
        1. Signaling Cell and Target Cell Relationship
          1. Specificity of Signal-Receptor Interaction
            1. Affinity and Receptor-Ligand Binding Kinetics
              1. Signal Transduction Cascade Concept
                1. Signal Amplification Mechanisms
                  1. Reversibility and Regulation of Signaling
                  2. Modes of Intercellular Signaling
                    1. Endocrine Signaling
                      1. Hormone Secretion into Bloodstream
                        1. Target Cell Recognition at Distance
                          1. Endocrine Hormone Examples
                          2. Paracrine Signaling
                            1. Local Mediator Release
                              1. Diffusion and Range Limitations
                                1. Paracrine Factor Examples
                                2. Autocrine Signaling
                                  1. Self-Targeting Mechanisms
                                    1. Role in Development
                                      1. Role in Cancer
                                      2. Synaptic Signaling
                                        1. Synapse Structure
                                          1. Neurotransmitter Release
                                            1. Neurotransmitter Reception
                                              1. Speed of Synaptic Transmission
                                                1. Specificity of Synaptic Transmission
                                                2. Juxtacrine Signaling
                                                  1. Membrane-Bound Ligands
                                                    1. Membrane-Bound Receptors
                                                      1. Direct Cell-Cell Contact Requirement
                                                        1. Examples in Development
                                                          1. Examples in Immunity
                                                        2. Key Stages of Cell Signaling
                                                          1. Signal Reception
                                                            1. Ligand Binding to Receptors
                                                              1. Receptor Activation
                                                              2. Signal Transduction
                                                                1. Intracellular Relay Molecules
                                                                  1. Second Messenger Generation
                                                                    1. Signal Amplification Steps
                                                                    2. Cellular Response
                                                                      1. Changes in Gene Expression
                                                                        1. Alterations in Cellular Metabolism
                                                                          1. Modulation of Cell Behavior