Cell Signaling and Signal Transduction

  1. Signaling in Health and Disease
    1. Physiological Roles of Signaling
      1. Embryonic Development and Differentiation
        1. Pattern Formation
          1. Cell Fate Specification
          2. Tissue Homeostasis and Repair
            1. Wound Healing
              1. Stem Cell Regulation
              2. Immune System Function
                1. Lymphocyte Activation
                  1. Cytokine Signaling in Immunity
                  2. Nervous System Function
                    1. Synaptic Plasticity
                      1. Neurotransmitter Signaling
                    2. Dysregulation of Signaling in Disease
                      1. Cancer
                        1. Oncogenes
                          1. Tumor Suppressors
                            1. Aberrant RTK Signaling
                              1. Aberrant Ras Signaling
                              2. Diabetes and Metabolic Syndrome
                                1. Insulin Signaling Pathway Defects
                                  1. Glucose Homeostasis
                                  2. Inflammatory and Autoimmune Diseases
                                    1. Chronic Cytokine Signaling
                                      1. NF-κB Pathway Dysregulation
                                      2. Neurological and Psychiatric Disorders
                                        1. Neurotransmitter Imbalance
                                          1. Synaptic Signaling Defects
                                        2. Principles of Pharmacological Intervention
                                          1. Receptor Agonists
                                            1. Receptor Antagonists
                                              1. Enzyme Inhibitors
                                                1. Kinase Inhibitors
                                                  1. Phosphodiesterase Inhibitors
                                                  2. Monoclonal Antibodies
                                                    1. Targeting Receptors
                                                      1. Targeting Ligands
                                                      2. Targeting Second Messenger Systems
                                                        1. Modulation of cAMP Levels
                                                          1. Modulation of cGMP Levels
                                                            1. Calcium Channel Blockers

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                                                        9. Cellular Responses to Signaling

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                                                        1. Fundamentals of Cell Communication