Cell Signaling and Signal Transduction

  1. Other Major Signaling Pathways
    1. Notch Signaling Pathway
      1. Structure of Notch Receptor
        1. Delta/Serrate/Lag-2 Ligands
          1. Ligand-Induced Proteolytic Cleavage
            1. Release of Notch Intracellular Domain
              1. Nuclear Translocation of Notch Intracellular Domain
                1. Regulation of Cell Fate Decisions
                2. Wnt Signaling Pathway
                  1. Wnt Ligands
                    1. Frizzled Receptors
                      1. β-catenin Destruction Complex
                        1. Axin
                          1. APC
                            1. GSK-3β
                            2. Canonical Pathway
                              1. Stabilization of β-catenin
                                1. Nuclear Translocation of β-catenin
                                  1. Activation of Wnt Target Genes
                                  2. Non-canonical Pathways
                                    1. Planar Cell Polarity Pathway
                                      1. Wnt/Ca2+ Pathway
                                    2. Hedgehog Signaling Pathway
                                      1. Hedgehog Ligands
                                        1. Sonic Hedgehog
                                          1. Indian Hedgehog
                                            1. Desert Hedgehog
                                            2. Patched Receptor
                                              1. Smoothened Receptor
                                                1. Role of Primary Cilia in Signal Transduction
                                                  1. Activation of Gli Transcription Factors
                                                    1. Regulation of Gli Transcription Factors
                                                      1. Control of Developmental Patterning
                                                      2. NF-κB Signaling Pathway
                                                        1. Activation by Pro-inflammatory Stimuli
                                                          1. Tumor Necrosis Factor-α
                                                            1. Interleukin-1
                                                            2. IKK Complex Activation
                                                              1. Phosphorylation of IκB
                                                                1. Degradation of IκB
                                                                  1. Nuclear Translocation of NF-κB
                                                                    1. Regulation of Immune Responses
                                                                      1. Regulation of Inflammatory Responses