Cell Signaling and Signal Transduction

  1. Cellular Receptors
    1. Intracellular Receptors
      1. Location
        1. Cytoplasmic Receptors
          1. Nuclear Receptors
          2. Mechanism of Action
            1. Ligand-Activated Transcription Factors
              1. DNA Binding Domains
                1. Hormone Response Elements
                2. Steroid Hormone Receptor Superfamily
                  1. Glucocorticoid Receptors
                    1. Estrogen Receptors
                      1. Androgen Receptors
                    2. Cell-Surface Receptors
                      1. General Structure and Function
                        1. Extracellular Ligand-Binding Domain
                          1. Transmembrane Domain
                            1. Intracellular Signaling Domain
                            2. Ion Channel-Linked Receptors
                              1. Structure of Ligand-Gated Ion Channels
                                1. Mechanism of Channel Opening
                                  1. Nicotinic Acetylcholine Receptor
                                  2. G-Protein Coupled Receptors
                                    1. Seven-Transmembrane Domain Structure
                                      1. Ligand Binding Sites
                                        1. Coupling to G-Proteins
                                        2. Enzyme-Linked Receptors
                                          1. Receptor Tyrosine Kinases
                                            1. Receptor Serine/Threonine Kinases
                                              1. Receptor Guanylyl Cyclases

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                                          2. Signaling Molecules

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                                          4. G-Protein Coupled Receptor Pathways