Bacterial Pathogenesis

  1. Virulence Gene Regulation
    1. Environmental Sensing Systems
      1. Two-Component Regulatory Systems
        1. Histidine Kinase Sensors
          1. Response Regulator Proteins
            1. Phosphorylation Cascades
              1. Signal Transduction Pathways
              2. Environmental Parameter Sensing
                1. Temperature Sensing
                  1. pH Sensing
                    1. Osmolarity Detection
                      1. Oxygen Availability
                        1. Nutrient Limitation
                        2. Host Signal Recognition
                          1. Hormone Detection
                            1. Host Cell Contact
                              1. Tissue-Specific Signals
                                1. Inflammatory Mediators
                              2. Quorum Sensing Systems
                                1. Autoinducer Molecules
                                  1. Acyl-Homoserine Lactones
                                    1. Peptide Autoinducers
                                      1. Autoinducer-2 Systems
                                        1. Species-Specific Signals
                                        2. Quorum Sensing Circuits
                                          1. Signal Synthesis
                                            1. Signal Detection
                                              1. Response Regulation
                                                1. Feedback Loops
                                                2. Quorum Sensing Functions
                                                  1. Virulence Gene Regulation
                                                    1. Biofilm Formation Control
                                                      1. Metabolic Coordination
                                                        1. Competence Development
                                                      2. Global Regulatory Networks
                                                        1. Master Regulatory Proteins
                                                          1. Transcriptional Activators
                                                            1. Transcriptional Repressors
                                                              1. Sigma Factor Regulation
                                                              2. Regulatory RNA Molecules
                                                                1. Small Regulatory RNAs
                                                                  1. Riboswitches
                                                                    1. Antisense RNAs
                                                                    2. Post-Translational Regulation
                                                                      1. Protein Modification
                                                                        1. Proteolytic Control
                                                                          1. Allosteric Regulation
                                                                        2. Phase Variation Systems
                                                                          1. DNA Inversion Systems
                                                                            1. Site-Specific Recombination
                                                                              1. Invertible DNA Elements
                                                                              2. Slipped-Strand Mispairing
                                                                                1. Simple Sequence Repeats
                                                                                  1. Frameshift Mutations
                                                                                  2. Methylation-Based Switching
                                                                                    1. Dam Methylation
                                                                                      1. Restriction-Modification Systems
                                                                                      2. Functional Consequences
                                                                                        1. Surface Antigen Variation
                                                                                          1. Virulence Factor Expression
                                                                                            1. Host Adaptation

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                                                                                        7. Mechanisms of Host Tissue Damage

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                                                                                        9. Genetics of Bacterial Pathogenicity