Bacterial Pathogenesis

  1. Bacterial Adhesion and Colonization
    1. Overcoming Host Physical Defenses
      1. Mucus Layer Penetration
        1. Mucus Composition and Properties
          1. Bacterial Mucinases
            1. Motility Through Mucus
            2. Ciliary Action Evasion
              1. Respiratory Tract Cilia Function
                1. Bacterial Inhibition of Ciliary Beat
                  1. Cytotoxic Effects on Ciliated Cells
                  2. Peristalsis Resistance
                    1. Gastrointestinal Motility
                      1. Bacterial Adherence Strategies
                        1. Biofilm Formation in Flow Conditions
                      2. Bacterial Adhesion Mechanisms
                        1. Fimbrial Adhesins
                          1. Type 1 Fimbriae
                            1. P Fimbriae
                              1. Fimbrial Structure and Assembly
                                1. Tissue Specificity
                                2. Non-Fimbrial Adhesins
                                  1. Outer Membrane Proteins
                                    1. Surface-Associated Proteins
                                      1. Lipoteichoic Acid in Gram-Positive Bacteria
                                      2. Pili and Adhesion
                                        1. Type IV Pili
                                          1. Pilus Biogenesis
                                            1. Twitching Motility
                                            2. Capsules and Glycocalyx
                                              1. Capsular Polysaccharides
                                                1. Slime Layer Formation
                                                  1. Role in Surface Attachment
                                                2. Host Cell Receptors
                                                  1. Carbohydrate Receptors
                                                    1. Protein Receptors
                                                      1. Lipid Receptors
                                                        1. Receptor Specificity and Tropism
                                                        2. Biofilm Formation and Maturation
                                                          1. Initial Attachment Phase
                                                            1. Reversible Attachment
                                                              1. Irreversible Attachment
                                                                1. Surface Conditioning
                                                                2. Biofilm Development Stages
                                                                  1. Microcolony Formation
                                                                    1. Biofilm Maturation
                                                                      1. Three-Dimensional Architecture
                                                                        1. Dispersal and Detachment
                                                                        2. Extracellular Polymeric Substances
                                                                          1. Polysaccharides
                                                                            1. Proteins
                                                                              1. Nucleic Acids
                                                                                1. Lipids
                                                                                2. Quorum Sensing in Biofilms
                                                                                  1. Signaling Molecules
                                                                                    1. Population Density Sensing
                                                                                      1. Coordinated Gene Expression
                                                                                      2. Biofilm-Associated Infections
                                                                                        1. Chronic Infection Development
                                                                                          1. Antibiotic Resistance Mechanisms
                                                                                            1. Immune Evasion Properties

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                                                                                        2. Bacterial Transmission and Host Entry

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                                                                                        4. Bacterial Invasion and Tissue Spread