Bacterial Pathogenesis

  1. Experimental Approaches to Pathogenesis
    1. In Vitro Model Systems
      1. Cell Culture Models
        1. Primary Cell Cultures
          1. Immortalized Cell Lines
            1. Tissue-Specific Cell Types
              1. Co-Culture Systems
              2. Organoid Technology
                1. Three-Dimensional Culture
                  1. Tissue Architecture Mimicry
                    1. Organ-Specific Function
                      1. Disease Modeling Applications
                      2. Artificial Tissue Models
                        1. Bioengineered Tissues
                          1. Microfluidic Systems
                            1. Organ-on-Chip Technology
                          2. In Vivo Model Systems
                            1. Mammalian Models
                              1. Mouse Model Systems
                                1. Rat Models
                                  1. Non-Human Primate Models
                                    1. Humanized Mouse Models
                                    2. Alternative Animal Models
                                      1. Zebrafish Models
                                        1. Chicken Embryo Models
                                          1. Rabbit Models
                                          2. Invertebrate Models
                                            1. Caenorhabditis elegans
                                              1. Drosophila melanogaster
                                                1. Galleria mellonella
                                                  1. Advantages and Limitations
                                                2. Molecular and Genetic Tools
                                                  1. Gene Manipulation Techniques
                                                    1. Targeted Gene Deletion
                                                      1. Site-Directed Mutagenesis
                                                        1. Complementation Analysis
                                                          1. Conditional Gene Expression
                                                          2. Modern Genetic Tools
                                                            1. CRISPR-Cas Systems
                                                              1. Recombineering Techniques
                                                                1. Transposon Mutagenesis
                                                                  1. Random Mutagenesis
                                                                  2. Reporter Systems
                                                                    1. Fluorescent Protein Reporters
                                                                      1. Luminescent Reporters
                                                                        1. Enzymatic Reporters
                                                                          1. In Vivo Imaging Applications
                                                                          2. Genomic Approaches
                                                                            1. Whole Genome Sequencing
                                                                              1. Comparative Genomics
                                                                                1. Population Genomics
                                                                                  1. Phylogenetic Analysis
                                                                                  2. Transcriptomic Analysis
                                                                                    1. RNA Sequencing
                                                                                      1. Microarray Analysis
                                                                                        1. Single-Cell RNA Sequencing
                                                                                          1. Temporal Expression Profiling
                                                                                          2. Proteomic Approaches
                                                                                            1. Mass Spectrometry Analysis
                                                                                              1. Protein-Protein Interactions
                                                                                                1. Post-Translational Modifications
                                                                                                  1. Secretome Analysis
                                                                                                  2. Metabolomic Studies
                                                                                                    1. Metabolite Profiling
                                                                                                      1. Metabolic Pathway Analysis
                                                                                                        1. Host-Pathogen Metabolic Interactions

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                                                                                                    9. Genetics of Bacterial Pathogenicity

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                                                                                                    1. Introduction to Bacterial Pathogenesis