Lipid Chemistry and Metabolism

  1. Biological Membranes
    1. Membrane Models and Structure
      1. Historical Development
        1. Lipid Bilayer Model
          1. Unit Membrane Model
            1. Fluid Mosaic Model
            2. Key Features of the Fluid Mosaic Model
              1. Lipid Bilayer Matrix
                1. Integral and Peripheral Proteins
                  1. Dynamic Nature
                2. Lipid Bilayer Structure
                  1. Spontaneous Assembly in Aqueous Solution
                    1. Thermodynamic Driving Forces
                      1. Critical Packing Parameter
                      2. Bilayer Properties
                        1. Thickness
                          1. Permeability
                            1. Stability
                            2. Membrane Asymmetry
                              1. Transbilayer Distribution of Lipids
                                1. Functional Consequences
                                  1. Maintenance of Asymmetry
                                  2. Inner and Outer Leaflets
                                    1. Compositional Differences
                                      1. Functional Specialization
                                    2. Membrane Fluidity
                                      1. Factors Affecting Fluidity
                                        1. Fatty Acid Chain Length
                                          1. Degree of Unsaturation
                                            1. Double Bond Configuration
                                              1. Cholesterol Content
                                              2. Temperature Effects
                                                1. Phase Transitions
                                                  1. Homeoviscous Adaptation
                                                  2. Biological Significance
                                                    1. Membrane Function
                                                      1. Protein Activity
                                                        1. Transport Processes
                                                      2. Membrane Microdomains
                                                        1. Lipid Rafts
                                                          1. Composition and Structure
                                                            1. Cholesterol and Sphingolipid Enrichment
                                                              1. Protein Associations
                                                              2. Functional Roles
                                                                1. Signal Transduction
                                                                  1. Membrane Trafficking
                                                                    1. Pathogen Entry
                                                                    2. Caveolae
                                                                      1. Structure and Composition
                                                                        1. Functions in Endocytosis