Lipid Chemistry and Metabolism

  1. Structural Lipids in Membranes
    1. Glycerophospholipids
      1. Basic Structure
        1. Phosphatidic Acid as Parent Compound
          1. sn-1 and sn-2 Positions
            1. Phosphate Group at sn-3 Position
            2. Major Classes Based on Head Groups
              1. Phosphatidylcholine (Lecithin)
                1. Structure and Properties
                  1. Biological Functions
                  2. Phosphatidylethanolamine (Cephalin)
                    1. Structure and Properties
                      1. Biological Functions
                      2. Phosphatidylserine
                        1. Structure and Properties
                          1. Role in Apoptosis Signaling
                          2. Phosphatidylinositol
                            1. Structure and Properties
                              1. Phosphorylated Derivatives
                              2. Phosphatidylglycerol
                                1. Structure and Properties
                                  1. Role in Bacterial Membranes
                                  2. Cardiolipin
                                    1. Structure and Properties
                                      1. Role in Mitochondrial Membranes
                                    2. Specialized Phospholipids
                                      1. Plasmalogens
                                        1. Structure and Distribution
                                          1. Biological Functions
                                          2. Platelet-Activating Factor
                                            1. Structure and Properties
                                              1. Biological Activities
                                            2. Functional Roles in Membranes
                                              1. Membrane Structure
                                                1. Membrane Dynamics
                                                  1. Enzyme Activation
                                                2. Sphingolipids
                                                  1. Sphingosine Backbone
                                                    1. Structure of Sphingosine
                                                      1. Biosynthetic Origin
                                                      2. Ceramides
                                                        1. Structure and Formation
                                                          1. Biological Functions
                                                            1. Role in Cell Death
                                                            2. Major Classes of Sphingolipids
                                                              1. Sphingomyelins
                                                                1. Structure and Properties
                                                                  1. Distribution in Membranes
                                                                    1. Functions in Myelin
                                                                    2. Glycosphingolipids
                                                                      1. General Structure
                                                                        1. Carbohydrate Attachment
                                                                        2. Cerebrosides (Neutral Glycolipids)
                                                                          1. Galactocerebrosides
                                                                            1. Glucocerebrosides
                                                                            2. Globosides
                                                                              1. Structure and Distribution
                                                                                1. Blood Group Antigens
                                                                                2. Gangliosides (Acidic Glycolipids)
                                                                                  1. Structure with Sialic Acid
                                                                                    1. Distribution in Neural Tissue
                                                                                      1. Functions in Cell Recognition
                                                                                    2. Functions in Cell Recognition and Signaling
                                                                                      1. Cell Surface Markers
                                                                                        1. Receptor Functions
                                                                                          1. Signal Transduction
                                                                                        2. Sterols
                                                                                          1. Steroid Nucleus Structure
                                                                                            1. Four-Ring System
                                                                                              1. Numbering Convention
                                                                                                1. Stereochemistry
                                                                                                2. Cholesterol
                                                                                                  1. Structure and Properties
                                                                                                    1. Hydroxyl Group at C-3
                                                                                                      1. Double Bond in B Ring
                                                                                                        1. Side Chain at C-17
                                                                                                        2. Physical Properties
                                                                                                          1. Membrane Interactions
                                                                                                            1. Solubility Characteristics
                                                                                                            2. Biological Functions
                                                                                                              1. Role in Membrane Fluidity
                                                                                                                1. Membrane Raft Formation
                                                                                                                  1. Precursor to Bile Acids
                                                                                                                    1. Precursor to Steroid Hormones
                                                                                                                      1. Precursor to Vitamin D
                                                                                                                    2. Other Sterols
                                                                                                                      1. Plant Sterols
                                                                                                                        1. Ergosterol in Fungi

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                                                                                                                    3. Storage Lipids: Triacylglycerols

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                                                                                                                    5. Biological Membranes