Immunology

  1. T Cell Biology
    1. T Cell Receptor Structure and Function
      1. TCR Components
        1. Alpha Chain
          1. Beta Chain
            1. CD3 Complex
              1. Zeta Chain
              2. Antigen Recognition
                1. MHC-Peptide Binding
                  1. Specificity Determinants
                    1. Affinity Interactions
                    2. TCR Diversity Generation
                      1. V(D)J Recombination
                        1. Junctional Diversity
                          1. Somatic Recombination
                        2. T Cell Development
                          1. Thymic Environment
                            1. Cortical Epithelial Cells
                              1. Medullary Epithelial Cells
                                1. Dendritic Cells
                                2. Developmental Stages
                                  1. Double-Negative Stage
                                    1. Double-Positive Stage
                                      1. Single-Positive Stage
                                      2. Selection Processes
                                        1. Positive Selection
                                          1. MHC Recognition
                                            1. Survival Signals
                                            2. Negative Selection
                                              1. Self-Tolerance Induction
                                                1. Apoptosis Mechanisms
                                            3. T Cell Activation
                                              1. Signal Requirements
                                                1. Signal 1: TCR Engagement
                                                  1. Signal 2: Costimulation
                                                    1. Signal 3: Cytokine Signals
                                                    2. Costimulatory Molecules
                                                      1. CD28-B7 Interaction
                                                        1. ICOS-ICOSL
                                                          1. Additional Costimulatory Pathways
                                                          2. Immunological Synapse
                                                            1. Formation Process
                                                              1. Molecular Organization
                                                                1. Signal Integration
                                                                2. T Cell Anergy
                                                                  1. Induction Mechanisms
                                                                    1. Molecular Basis
                                                                      1. Functional Consequences
                                                                    2. T Cell Subsets
                                                                      1. Helper T Cell Differentiation
                                                                        1. Th1 Cells
                                                                          1. Transcription Factors
                                                                            1. Cytokine Profile
                                                                              1. Effector Functions
                                                                              2. Th2 Cells
                                                                                1. Transcription Factors
                                                                                  1. Cytokine Profile
                                                                                    1. Effector Functions
                                                                                    2. Th17 Cells
                                                                                      1. Transcription Factors
                                                                                        1. Cytokine Profile
                                                                                          1. Effector Functions
                                                                                          2. Follicular Helper T Cells
                                                                                            1. Transcription Factors
                                                                                              1. B Cell Help
                                                                                                1. Germinal Center Function
                                                                                              2. Cytotoxic T Lymphocytes
                                                                                                1. Activation Requirements
                                                                                                  1. Cytotoxic Mechanisms
                                                                                                    1. Perforin-Granzyme Pathway
                                                                                                      1. Fas-FasL Pathway
                                                                                                      2. Target Cell Recognition
                                                                                                      3. Regulatory T Cells
                                                                                                        1. Natural Tregs
                                                                                                          1. Thymic Development
                                                                                                            1. FoxP3 Expression
                                                                                                            2. Induced Tregs
                                                                                                              1. Peripheral Induction
                                                                                                                1. Suppressive Mechanisms
                                                                                                              2. Memory T Cells
                                                                                                                1. Central Memory T Cells
                                                                                                                  1. Effector Memory T Cells
                                                                                                                    1. Tissue-Resident Memory T Cells

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                                                                                                                4. Adaptive Immunity Fundamentals

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                                                                                                                6. B Cell Biology and Antibody Responses