Immunology

  1. Adaptive Immunity Fundamentals
    1. Antigens and Antigenicity
      1. Antigen Structure
        1. Molecular Composition
          1. Size Requirements
            1. Structural Complexity
            2. Epitope Types
              1. Linear Epitopes
                1. Conformational Epitopes
                  1. Epitope Mapping
                  2. Immunogenicity Factors
                    1. Foreignness
                      1. Molecular Size
                        1. Chemical Complexity
                          1. Route of Administration
                          2. Haptens and Carriers
                            1. Hapten Definition
                              1. Carrier Proteins
                                1. Hapten-Carrier Conjugates
                              2. Major Histocompatibility Complex
                                1. MHC Class I Molecules
                                  1. Structural Organization
                                    1. Tissue Distribution
                                      1. Peptide Binding Groove
                                        1. Beta-2 Microglobulin Association
                                        2. MHC Class II Molecules
                                          1. Structural Organization
                                            1. Tissue Distribution
                                              1. Peptide Binding Characteristics
                                                1. Alpha-Beta Chain Assembly
                                                2. MHC Genetics
                                                  1. Chromosomal Organization
                                                    1. Allelic Polymorphism
                                                      1. Inheritance Patterns
                                                        1. Population Genetics
                                                        2. MHC Restriction
                                                          1. T Cell Recognition
                                                            1. Self-MHC Recognition
                                                              1. Transplant Compatibility
                                                            2. Antigen Processing and Presentation
                                                              1. MHC Class I Pathway
                                                                1. Proteasomal Degradation
                                                                  1. TAP Transport
                                                                    1. ER Assembly
                                                                      1. Surface Expression
                                                                      2. MHC Class II Pathway
                                                                        1. Endocytic Processing
                                                                          1. Invariant Chain Function
                                                                            1. CLIP Removal
                                                                              1. Peptide Loading
                                                                              2. Cross-Presentation
                                                                                1. Mechanisms
                                                                                  1. Dendritic Cell Function
                                                                                    1. Viral Immunity

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                                                                                3. Innate Immunity

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                                                                                5. T Cell Biology