Immunology

  1. Innate Immunity
    1. Physical and Chemical Barriers
      1. Skin Barriers
        1. Structural Components
          1. Antimicrobial Properties
            1. Barrier Function
            2. Mucous Membrane Barriers
              1. Mucociliary Clearance
                1. Secreted Antimicrobial Factors
                  1. Commensal Microbiota
                  2. Chemical Defense Mechanisms
                    1. pH and Acidic Environments
                      1. Antimicrobial Enzymes
                        1. Defensins and Antimicrobial Peptides
                      2. Pattern Recognition Systems
                        1. Pathogen-Associated Molecular Patterns
                          1. Bacterial PAMPs
                            1. Viral PAMPs
                              1. Fungal PAMPs
                              2. Damage-Associated Molecular Patterns
                                1. Endogenous Danger Signals
                                  1. Sources of DAMPs
                                    1. Recognition Mechanisms
                                    2. Pattern Recognition Receptors
                                      1. Toll-like Receptors
                                        1. TLR Families
                                          1. Ligand Recognition
                                            1. Signaling Pathways
                                              1. Cellular Distribution
                                              2. NOD-like Receptors
                                                1. Structure and Function
                                                  1. Inflammasome Formation
                                                    1. Inflammatory Responses
                                                    2. RIG-I-like Receptors
                                                      1. Viral RNA Recognition
                                                        1. Signaling Mechanisms
                                                        2. C-type Lectin Receptors
                                                          1. Carbohydrate Recognition
                                                            1. Fungal Detection
                                                        3. Complement System
                                                          1. Activation Pathways
                                                            1. Classical Pathway
                                                              1. Antibody-Dependent Activation
                                                                1. C1 Complex Function
                                                                2. Alternative Pathway
                                                                  1. Spontaneous Activation
                                                                    1. Amplification Loop
                                                                    2. Lectin Pathway
                                                                      1. Mannose-Binding Lectin
                                                                        1. Ficolin Recognition
                                                                      2. Complement Functions
                                                                        1. Opsonization
                                                                          1. C3b Deposition
                                                                            1. Complement Receptors
                                                                            2. Inflammatory Responses
                                                                              1. Anaphylatoxin Generation
                                                                                1. Cellular Activation
                                                                                2. Membrane Attack Complex
                                                                                  1. Assembly Process
                                                                                    1. Cell Lysis Mechanisms
                                                                                  2. Complement Regulation
                                                                                    1. Regulatory Proteins
                                                                                      1. Control Mechanisms
                                                                                    2. Inflammatory Responses
                                                                                      1. Acute Inflammation
                                                                                        1. Vascular Changes
                                                                                          1. Vasodilation
                                                                                            1. Increased Permeability
                                                                                            2. Cellular Recruitment
                                                                                              1. Chemokine Gradients
                                                                                                1. Leukocyte Adhesion
                                                                                                  1. Extravasation Process
                                                                                                  2. Resolution Mechanisms
                                                                                                    1. Anti-inflammatory Mediators
                                                                                                      1. Tissue Repair
                                                                                                    2. Chronic Inflammation
                                                                                                      1. Persistent Stimuli
                                                                                                        1. Cellular Infiltration
                                                                                                          1. Tissue Remodeling
                                                                                                            1. Granuloma Formation
                                                                                                          2. Cytokine Networks in Innate Immunity
                                                                                                            1. Pro-inflammatory Cytokines
                                                                                                              1. Interleukin-1
                                                                                                                1. Tumor Necrosis Factor-alpha
                                                                                                                  1. Interleukin-6
                                                                                                                  2. Type I Interferons
                                                                                                                    1. Antiviral Responses
                                                                                                                      1. Cellular Activation
                                                                                                                      2. Chemokines
                                                                                                                        1. Classification Systems
                                                                                                                          1. Cellular Migration
                                                                                                                            1. Tissue Homing

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                                                                                                                        2. Cells and Organs of the Immune System

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                                                                                                                        4. Adaptive Immunity Fundamentals