Cellular and Molecular Neuroscience

  1. Neural Development
    1. Genesis of the Nervous System
      1. Neurulation
        1. Formation of the Neural Tube
          1. Neural Plate Formation
            1. Neural Crest Cells
            2. Proliferation of Neural Progenitor Cells
              1. Symmetric and Asymmetric Division
                1. Cell Cycle Regulation
                  1. Progenitor Cell Types
                  2. Neurogenesis and Gliogenesis
                    1. Timing and Regulation
                      1. Transcription Factor Control
                        1. Adult Neurogenesis
                      2. Neuronal Migration
                        1. Radial Migration
                          1. Radial Glial Scaffolds
                            1. Migration Mechanisms
                            2. Tangential Migration
                              1. Interneuron Migration
                                1. Migration Pathways
                                2. Guidance Mechanisms
                                  1. Molecular Cues
                                    1. Environmental Factors
                                  2. Differentiation and Axon Guidance
                                    1. Neuronal Differentiation
                                      1. Cell Fate Determination
                                        1. Transcriptional Programs
                                        2. The Growth Cone
                                          1. Structure and Dynamics
                                            1. Actin and Microtubule Organization
                                              1. Growth Cone Collapse
                                              2. Axon Guidance Cues
                                                1. Chemoattraction
                                                  1. Netrins
                                                    1. Growth Factors
                                                      1. Morphogens
                                                      2. Chemorepulsion
                                                        1. Semaphorins
                                                          1. Slits
                                                            1. Ephrins
                                                            2. Contact-Mediated Guidance
                                                              1. Cell Adhesion Molecules
                                                                1. Extracellular Matrix Molecules
                                                                  1. Substrate Adhesion
                                                                2. Pathfinding Mechanisms
                                                                  1. Pioneer Neurons
                                                                    1. Fasciculation
                                                                      1. Intermediate Targets
                                                                    2. Synaptogenesis
                                                                      1. Formation of Synaptic Connections
                                                                        1. Synaptic Target Selection
                                                                          1. Synaptic Maturation
                                                                            1. Presynaptic Differentiation
                                                                              1. Postsynaptic Differentiation
                                                                              2. Role of Cell Adhesion Molecules
                                                                                1. Cadherins
                                                                                  1. Neurexins and Neuroligins
                                                                                    1. SynCAMs
                                                                                    2. Activity-Dependent Synapse Formation
                                                                                      1. Role of Neural Activity
                                                                                        1. Calcium Signaling
                                                                                      2. Synaptic Elimination and Refinement
                                                                                        1. Activity-Dependent Competition
                                                                                          1. Hebbian Mechanisms
                                                                                            1. Use-It-or-Lose-It Principle
                                                                                            2. Synaptic Pruning
                                                                                              1. Developmental Pruning
                                                                                                1. Microglial Role
                                                                                                2. Programmed Cell Death (Apoptosis)
                                                                                                  1. Intrinsic and Extrinsic Pathways
                                                                                                    1. Caspase Activation
                                                                                                      1. Survival Factors
                                                                                                    2. Neurotrophic Factors
                                                                                                      1. Nerve Growth Factor (NGF)
                                                                                                        1. Discovery and Structure
                                                                                                          1. Receptors and Signaling
                                                                                                            1. Target-Derived Support
                                                                                                            2. Brain-Derived Neurotrophic Factor (BDNF)
                                                                                                              1. Structure and Function
                                                                                                                1. Receptors and Signaling
                                                                                                                  1. Activity-Dependent Release
                                                                                                                  2. Other Neurotrophins
                                                                                                                    1. NT-3
                                                                                                                      1. NT-4/5
                                                                                                                        1. Neurotrophin Receptors
                                                                                                                        2. Other Growth Factors
                                                                                                                          1. GDNF Family
                                                                                                                            1. FGF Family
                                                                                                                              1. IGF Family
                                                                                                                            2. Critical Periods
                                                                                                                              1. Definition and Characteristics
                                                                                                                                1. Molecular Mechanisms
                                                                                                                                  1. Examples in Different Systems

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                                                                                                                                8. Synaptic Plasticity

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                                                                                                                                10. Molecular Basis of Neurological Disease