Cellular and Molecular Neuroscience

  1. The Neuronal Membrane and Electrical Potentials
    1. The Phospholipid Bilayer
      1. Membrane Structure
        1. Fluid Mosaic Model
          1. Selective Permeability
            1. Membrane Composition
              1. Phospholipids
                1. Cholesterol
                  1. Membrane Proteins
                2. Membrane Proteins
                  1. Ion Channels
                    1. Types of Ion Channels
                      1. Voltage-Gated Channels
                        1. Ligand-Gated Channels
                          1. Leak Channels
                            1. Mechanosensitive Channels
                            2. Channel Selectivity
                              1. Channel Gating
                                1. Channel Structure
                                2. Ion Pumps
                                  1. ATPase Pumps
                                    1. Active Transport Mechanisms
                                      1. Energy Requirements
                                      2. Transporters and Exchangers
                                        1. Sodium-Calcium Exchanger
                                          1. Chloride Transporters
                                        2. The Resting Membrane Potential
                                          1. Ions as Charge Carriers
                                            1. Sodium (Na+)
                                              1. Potassium (K+)
                                                1. Chloride (Cl-)
                                                  1. Calcium (Ca2+)
                                                  2. Diffusion and Electrical Forces
                                                    1. Concentration Gradients
                                                      1. Electrochemical Gradients
                                                        1. Driving Forces
                                                        2. Equilibrium Potentials
                                                          1. The Nernst Equation
                                                            1. Calculation and Interpretation
                                                              1. Temperature Dependence
                                                            2. Ion Distribution Across the Membrane
                                                              1. Intracellular vs. Extracellular Ion Concentrations
                                                                1. Impermeant Anions
                                                                2. Relative Ion Permeability
                                                                  1. The Goldman-Hodgkin-Katz (GHK) Equation
                                                                    1. Determining Membrane Potential
                                                                      1. Permeability Ratios
                                                                    2. The Sodium-Potassium Pump
                                                                      1. Mechanism and Stoichiometry
                                                                        1. Role in Maintaining Gradients
                                                                          1. Electrogenic Nature
                                                                          2. The Calcium Pump
                                                                            1. Calcium Homeostasis
                                                                              1. Role in Signaling
                                                                                1. Calcium Buffering

                                                                            Previous

                                                                            2. The Structure of Neurons and Glia

                                                                            Go to top

                                                                            Next

                                                                            4. The Action Potential