Cellular and Molecular Neuroscience

  1. Molecular Basis of Neurological Disease
    1. Channelopathies
      1. Epilepsy
        1. Mutations in Ion Channels
          1. Sodium Channel Mutations
            1. Potassium Channel Mutations
              1. Calcium Channel Mutations
                1. GABA Receptor Mutations
                2. Migraine
                  1. Familial Hemiplegic Migraine
                    1. Calcium Channel Mutations
                      1. Spreading Depression
                      2. Ataxia
                        1. Spinocerebellar Ataxias
                          1. Ion Channel Dysfunction
                            1. Repeat Expansions
                            2. Periodic Paralysis
                              1. Muscle Channelopathies
                                1. Hypokalemic Paralysis
                                  1. Hyperkalemic Paralysis
                                2. Diseases of the Synapse (Synaptopathies)
                                  1. Autism Spectrum Disorders
                                    1. Synaptic Protein Mutations
                                      1. Neurexin-Neuroligin Pathway
                                        1. SHANK Proteins
                                          1. Synaptic Dysfunction
                                          2. Schizophrenia
                                            1. Glutamatergic Dysfunction
                                              1. Dopaminergic Dysfunction
                                                1. NMDA Receptor Hypofunction
                                                  1. Synaptic Pruning Abnormalities
                                                  2. Myasthenia Gravis
                                                    1. Autoimmune Attack on nAChRs
                                                      1. Neuromuscular Junction Dysfunction
                                                      2. Lambert-Eaton Syndrome
                                                        1. Calcium Channel Antibodies
                                                          1. Presynaptic Dysfunction
                                                        2. Neurodegenerative Disorders
                                                          1. Alzheimer's Disease
                                                            1. Amyloid-beta Plaques
                                                              1. Amyloid Precursor Protein Processing
                                                                1. Beta-Secretase and Gamma-Secretase
                                                                  1. Amyloid Cascade Hypothesis
                                                                  2. Neurofibrillary Tangles (Tau)
                                                                    1. Tau Hyperphosphorylation
                                                                      1. Microtubule Dysfunction
                                                                        1. Tau Propagation
                                                                        2. Synaptic Loss
                                                                          1. Neuroinflammation
                                                                            1. Cholinergic Dysfunction
                                                                            2. Parkinson's Disease
                                                                              1. Loss of Dopaminergic Neurons
                                                                                1. Alpha-synuclein and Lewy Bodies
                                                                                  1. Protein Aggregation
                                                                                    1. Prion-like Spread
                                                                                    2. Mitochondrial Dysfunction
                                                                                      1. Oxidative Stress
                                                                                        1. Neuroinflammation
                                                                                        2. Huntington's Disease
                                                                                          1. Huntingtin Protein and Polyglutamine Repeats
                                                                                            1. Neuronal Degeneration
                                                                                              1. Striatal Pathology
                                                                                                1. Transcriptional Dysregulation
                                                                                                2. Amyotrophic Lateral Sclerosis (ALS)
                                                                                                  1. Motor Neuron Degeneration
                                                                                                    1. SOD1 Mutations
                                                                                                      1. TDP-43 Pathology
                                                                                                        1. RNA Processing Defects
                                                                                                      2. Disorders of Myelination
                                                                                                        1. Multiple Sclerosis (MS)
                                                                                                          1. Demyelination in CNS
                                                                                                            1. Immune Mechanisms
                                                                                                              1. Oligodendrocyte Dysfunction
                                                                                                                1. Axonal Damage
                                                                                                                2. Guillain-Barré Syndrome
                                                                                                                  1. Demyelination in PNS
                                                                                                                    1. Autoimmune Mechanisms
                                                                                                                      1. Molecular Mimicry
                                                                                                                      2. Leukodystrophies
                                                                                                                        1. Genetic Myelin Disorders
                                                                                                                          1. Metabolic Defects
                                                                                                                        2. Neurodevelopmental Disorders
                                                                                                                          1. Intellectual Disability
                                                                                                                            1. Genetic Causes
                                                                                                                              1. Synaptic Dysfunction
                                                                                                                              2. Rett Syndrome
                                                                                                                                1. MeCP2 Mutations
                                                                                                                                  1. Transcriptional Regulation
                                                                                                                                  2. Fragile X Syndrome
                                                                                                                                    1. FMRP and Protein Synthesis
                                                                                                                                      1. Synaptic Plasticity Defects

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                                                                                                                                  9. Neural Development

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                                                                                                                                  1. Introduction to Cellular and Molecular Neuroscience