Biophysical Chemistry

  1. Structural Determination Methods
    1. X-ray Crystallography
      1. Crystal Formation
        1. Nucleation and Growth
          1. Crystallization Conditions
            1. Crystal Quality Assessment
            2. Diffraction Theory
              1. Bragg's Law
                1. Structure Factors
                  1. Reciprocal Space
                  2. Data Collection
                    1. X-ray Sources
                      1. Detector Systems
                        1. Data Processing
                        2. Phase Problem
                          1. Isomorphous Replacement
                            1. Anomalous Scattering
                              1. Molecular Replacement
                              2. Structure Refinement
                                1. Electron Density Maps
                                  1. Model Building
                                    1. Validation Methods
                                  2. NMR Spectroscopy
                                    1. Nuclear Spin Properties
                                      1. Magnetic Moments
                                        1. Larmor Precession
                                          1. Relaxation Processes
                                          2. Chemical Shifts
                                            1. Shielding Effects
                                              1. Reference Standards
                                                1. Secondary Structure Correlations
                                                2. Scalar Coupling
                                                  1. Through-Bond Interactions
                                                    1. Coupling Constants
                                                      1. Multiplet Analysis
                                                      2. Nuclear Overhauser Effect
                                                        1. Distance Constraints
                                                          1. NOE Spectroscopy
                                                            1. Structure Calculations
                                                            2. Multidimensional NMR
                                                              1. Two-Dimensional Techniques
                                                                1. Three-Dimensional Techniques
                                                                  1. Assignment Strategies
                                                                  2. Solution Structure Determination
                                                                    1. Distance Geometry
                                                                      1. Molecular Dynamics
                                                                        1. Structure Validation
                                                                      2. Cryo-Electron Microscopy
                                                                        1. Sample Preparation
                                                                          1. Vitrification Techniques
                                                                            1. Grid Preparation
                                                                              1. Specimen Preservation
                                                                              2. Image Formation
                                                                                1. Electron Optics
                                                                                  1. Contrast Transfer Function
                                                                                    1. Radiation Damage
                                                                                    2. Single-Particle Analysis
                                                                                      1. Particle Selection
                                                                                        1. Classification Methods
                                                                                          1. Three-Dimensional Reconstruction
                                                                                          2. Resolution Assessment
                                                                                            1. Fourier Shell Correlation
                                                                                              1. Local Resolution
                                                                                                1. Model Validation
                                                                                              2. Small-Angle Scattering
                                                                                                1. SAXS Principles
                                                                                                  1. Scattering Theory
                                                                                                    1. Experimental Setup
                                                                                                      1. Data Analysis
                                                                                                      2. SANS Applications
                                                                                                        1. Contrast Variation
                                                                                                          1. Deuteration Strategies
                                                                                                            1. Membrane Studies
                                                                                                            2. Shape Determination
                                                                                                              1. Guinier Analysis
                                                                                                                1. Kratky Plots
                                                                                                                  1. Ab Initio Modeling

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                                                                                                              8. Spectroscopic Methods

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                                                                                                              10. Hydrodynamics and Transport