Biophysical Chemistry

  1. Molecular Interactions and Binding
    1. Binding Equilibria
      1. Binding Isotherms
        1. Saturation Curves
          1. Scatchard Analysis
            1. Hill Analysis
            2. Thermodynamic Parameters
              1. Binding Enthalpy
                1. Binding Entropy
                  1. Heat Capacity Changes
                  2. Cooperativity
                    1. Positive Cooperativity
                      1. Negative Cooperativity
                        1. Allosteric Models
                      2. Experimental Methods
                        1. Isothermal Titration Calorimetry
                          1. Instrumentation
                            1. Data Analysis
                              1. Thermodynamic Characterization
                              2. Surface Plasmon Resonance
                                1. Sensor Chip Technology
                                  1. Kinetic Analysis
                                    1. Affinity Measurements
                                    2. Fluorescence-Based Assays
                                      1. Fluorescence Polarization
                                        1. FRET-Based Assays
                                          1. Quenching Studies
                                          2. NMR Titrations
                                            1. Chemical Shift Mapping
                                              1. Line Broadening Analysis
                                                1. Exchange Kinetics
                                              2. Protein-Ligand Interactions
                                                1. Binding Site Characterization
                                                  1. Structure-Activity Relationships
                                                    1. Drug Design Applications
                                                      1. Allosteric Regulation
                                                      2. Protein-Protein Interactions
                                                        1. Interface Analysis
                                                          1. Binding Kinetics
                                                            1. Complex Stability
                                                              1. Regulatory Networks
                                                              2. Protein-Nucleic Acid Interactions
                                                                1. Sequence-Specific Binding
                                                                  1. Non-Specific Binding
                                                                    1. Cooperative Binding
                                                                      1. Regulatory Mechanisms

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                                                                    12. Statistical Mechanics Applications