Radiation Biology

  1. Cellular Radiobiology
    1. Cell Cycle and Radiosensitivity
      1. Cell Cycle Phases
        1. G1 Phase Characteristics
          1. S Phase DNA Synthesis
            1. G2 Phase Preparation
              1. M Phase Mitosis
                1. G0 Quiescent State
                2. Radiosensitivity Variations
                  1. Most Sensitive Phases
                    1. Most Resistant Phases
                      1. Molecular Basis of Sensitivity
                      2. Cell Cycle Checkpoints
                        1. G1/S Checkpoint
                          1. DNA Damage Detection
                            1. p53-Mediated Response
                            2. Intra-S Phase Checkpoint
                              1. Replication Fork Protection
                              2. G2/M Checkpoint
                                1. DNA Damage and Repair Verification
                                2. Spindle Assembly Checkpoint
                                3. Checkpoint Defects and Radiosensitivity
                                4. Cell Survival Analysis
                                  1. Clonogenic Assay
                                    1. Principles and Methodology
                                      1. Plating Efficiency
                                        1. Surviving Fraction Calculations
                                        2. Cell Survival Models
                                          1. Target Theory
                                            1. Single-Target Single-Hit Model
                                              1. Multi-Target Single-Hit Model
                                              2. Linear-Quadratic Model
                                                1. Mathematical Formulation
                                                  1. Alpha and Beta Components
                                                    1. Alpha/Beta Ratio
                                                      1. Clinical Applications
                                                      2. Other Mathematical Models
                                                      3. Survival Curve Parameters
                                                        1. D0 and Dq Values
                                                          1. Extrapolation Number
                                                            1. Mean Lethal Dose
                                                          2. Mechanisms of Cell Death
                                                            1. Mitotic Catastrophe
                                                              1. Chromosome Aberrations
                                                                1. Mitotic Failure
                                                                  1. Multinucleation
                                                                  2. Apoptosis
                                                                    1. Intrinsic Pathway
                                                                      1. Extrinsic Pathway
                                                                        1. p53-Dependent Apoptosis
                                                                          1. Radiation-Induced Apoptosis
                                                                          2. Necrosis
                                                                            1. Characteristics
                                                                              1. Inflammatory Response
                                                                              2. Autophagy
                                                                                1. Protective vs. Destructive Roles
                                                                                  1. Radiation-Induced Autophagy
                                                                                  2. Cellular Senescence
                                                                                    1. Permanent Growth Arrest
                                                                                      1. Senescence-Associated Secretory Phenotype
                                                                                      2. Ferroptosis
                                                                                      3. Chromosomal Aberrations
                                                                                        1. Types of Aberrations
                                                                                          1. Chromosome-Type Aberrations
                                                                                            1. Formation in G1 Phase
                                                                                              1. Examples and Characteristics
                                                                                              2. Chromatid-Type Aberrations
                                                                                                1. Formation in S/G2 Phase
                                                                                                  1. Examples and Characteristics
                                                                                                2. Stable Aberrations
                                                                                                  1. Reciprocal Translocations
                                                                                                    1. Inversions
                                                                                                      1. Insertions
                                                                                                        1. Ring Chromosomes
                                                                                                        2. Unstable Aberrations
                                                                                                          1. Dicentric Chromosomes
                                                                                                            1. Centric Rings
                                                                                                              1. Anaphase Bridges
                                                                                                                1. Fragments
                                                                                                                2. Complex Aberrations
                                                                                                                  1. Detection Methods
                                                                                                                    1. Conventional Cytogenetics
                                                                                                                      1. Fluorescence In Situ Hybridization
                                                                                                                        1. Chromosome Painting
                                                                                                                          1. Automated Scoring Systems
                                                                                                                          2. Dose-Response Relationships
                                                                                                                          3. Cellular Response Pathways
                                                                                                                            1. DNA Damage Response
                                                                                                                              1. Sensor Proteins
                                                                                                                                1. Signal Transduction
                                                                                                                                  1. Effector Mechanisms
                                                                                                                                  2. Stress Response Pathways
                                                                                                                                    1. Heat Shock Response
                                                                                                                                      1. Oxidative Stress Response
                                                                                                                                      2. Inflammatory Responses
                                                                                                                                        1. Cytokine Production
                                                                                                                                          1. NF-κB Activation

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                                                                                                                                      3. Molecular Radiobiology

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                                                                                                                                      5. Tissue and Organ Effects