Radiation Biology

  1. The Chemistry of Radiation Biology
    1. Mechanisms of Radiation Action
      1. Direct Action of Radiation
        1. Definition and Characteristics
          1. Target Molecules
            1. Energy Deposition Patterns
            2. Indirect Action of Radiation
              1. Definition and Characteristics
                1. Role of Water Radiolysis
                  1. Relative Importance in Biological Systems
                  2. Mixed Direct and Indirect Effects
                  3. Radiolysis of Water
                    1. Primary Events in Water Radiolysis
                      1. Energy Deposition in Water
                        1. Formation of Ion Pairs
                          1. Thermalization Processes
                          2. Formation of Reactive Species
                            1. Primary Radicals
                              1. Hydroxyl Radical
                                1. Hydrated Electron
                                  1. Hydrogen Atom
                                  2. Secondary Radicals
                                    1. Superoxide Radical
                                      1. Hydroperoxyl Radical
                                      2. Molecular Products
                                        1. Hydrogen Peroxide
                                          1. Hydrogen Gas
                                            1. Oxygen
                                          2. Radiation Chemical Yields
                                            1. G-Values
                                              1. Factors Affecting Yields
                                              2. Spatial Distribution of Radiolysis Products
                                                1. Track Structure
                                                  1. Spur Diffusion
                                                    1. Homogeneous vs. Heterogeneous Distribution
                                                  2. Chemical Reactions of Radiation Products
                                                    1. Radical-Radical Reactions
                                                      1. Radical-Molecule Reactions
                                                        1. Role of Oxygen in Radiolysis
                                                          1. Scavenging Reactions
                                                          2. Timescale of Radiation Effects
                                                            1. Physical Stage
                                                              1. Energy Deposition Events
                                                                1. Duration and Processes
                                                                2. Physicochemical Stage
                                                                  1. Formation of Excited States
                                                                    1. Ionization Events
                                                                      1. Thermalization
                                                                      2. Chemical Stage
                                                                        1. Radical Formation
                                                                          1. Diffusion Processes
                                                                            1. Chemical Reactions
                                                                            2. Biological Stage
                                                                              1. Molecular Damage
                                                                                1. Cellular Responses
                                                                                  1. Tissue Effects
                                                                                    1. Long-term Consequences

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                                                                                1. Fundamentals of Radiation Physics

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                                                                                3. Molecular Radiobiology