Biostatistics

  1. Data Management and Quality
    1. Data Collection Planning
      1. Data Collection Instruments
        1. Questionnaire Design
          1. Case Report Forms
            1. Electronic Data Capture
            2. Variable Definition
              1. Operational Definitions
                1. Coding Schemes
                  1. Data Dictionaries
                  2. Quality Control Procedures
                    1. Training and Standardization
                      1. Monitoring and Auditing
                        1. Error Prevention Strategies
                      2. Data Cleaning and Preparation
                        1. Data Entry Verification
                          1. Double Data Entry
                            1. Range and Logic Checks
                              1. Consistency Verification
                              2. Outlier Detection
                                1. Statistical Methods
                                  1. Clinical Review
                                    1. Decision Rules
                                    2. Data Transformation
                                      1. Variable Recoding
                                        1. Scale Transformations
                                          1. Derived Variables
                                        2. Missing Data
                                          1. Missing Data Mechanisms
                                            1. Missing Completely at Random (MCAR)
                                              1. Missing at Random (MAR)
                                                1. Missing Not at Random (MNAR)
                                                2. Missing Data Patterns
                                                  1. Monotone vs Non-Monotone
                                                    1. Pattern Analysis
                                                    2. Handling Strategies
                                                      1. Complete Case Analysis
                                                        1. Available Case Analysis
                                                          1. Imputation Methods
                                                            1. Single Imputation
                                                              1. Multiple Imputation
                                                                1. Hot Deck Imputation
                                                                  1. Regression Imputation
                                                                2. Sensitivity Analysis
                                                                  1. Assessing Impact of Missing Data
                                                                    1. Alternative Assumptions
                                                                      1. Robustness of Results
                                                                    2. Data Security and Privacy
                                                                      1. Data De-identification
                                                                        1. Direct Identifiers
                                                                          1. Indirect Identifiers
                                                                            1. Safe Harbor Method
                                                                            2. Data Storage and Access
                                                                              1. Secure Storage Systems
                                                                                1. Access Controls
                                                                                  1. Audit Trails
                                                                                  2. Data Sharing Considerations
                                                                                    1. Privacy Protection
                                                                                      1. Regulatory Compliance

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                                                                                  18. Epidemiological Measures

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                                                                                  20. Statistical Software and Computing