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Engineering
Biochemical and Bioprocess Engineering
Bioreactor Design and Operation
1. Introduction to Bioprocess Engineering and Bioreactors
2. Fundamentals of Cell Growth and Metabolism
3. Mass Transfer in Bioreactors
4. Heat Transfer in Bioreactors
5. Bioreactor Design and Construction
6. Instrumentation, Measurement, and Control
7. Modes of Bioreactor Operation
8. Scale-Up and Scale-Down
9. Specialized Bioreactor Systems
10. Downstream Processing Interface
11. Validation and Regulatory Compliance
Scale-Up and Scale-Down
Scale-Up Fundamentals
Geometric Similarity
Linear Scale Factor
Area Scale Factor
Volume Scale Factor
Maintaining Proportions
Dynamic Similarity
Reynolds Number
Froude Number
Weber Number
Power Number
Kinematic Similarity
Velocity Profiles
Flow Patterns
Mixing Patterns
Scale-Up Criteria
Constant Power per Unit Volume
Power Input Scaling
Energy Dissipation
Mixing Intensity
Constant Impeller Tip Speed
Shear Rate Considerations
Cell Damage Prevention
Foam Formation Control
Constant Volumetric Mass Transfer Coefficient
Oxygen Transfer Scaling
Mass Transfer Limitations
Aeration Requirements
Constant Mixing Time
Homogenization Requirements
Nutrient Distribution
pH Uniformity
Criteria Selection
Process-Specific Considerations
Critical Parameter Identification
Trade-Off Analysis
Scale-Up Challenges
Transport Phenomena Changes
Heat Transfer Limitations
Mass Transfer Gradients
Momentum Transfer Effects
Environmental Gradients
pH Gradients
Dissolved Oxygen Gradients
Substrate Gradients
Temperature Gradients
Mechanical Stress Effects
Shear Sensitivity
Cell Damage Mechanisms
Protein Denaturation
Operational Challenges
Sterilization Scaling
Cleaning Validation
Control System Complexity
Scale-Down Models
Purpose and Applications
Process Understanding
Scale-Up Prediction
Process Optimization
Design Principles
Representative Conditions
Controlled Environment
Measurable Parameters
Scale-Down Reactor Types
Stirred Tank Reactors
Compartment Models
Parallel Reactor Systems
Validation Methods
Comparison Studies
Statistical Analysis
Model Verification
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7. Modes of Bioreactor Operation
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9. Specialized Bioreactor Systems