Bioreactor Design and Operation

  1. Fundamentals of Cell Growth and Metabolism
    1. Cell Culture Systems
      1. Prokaryotic Cell Cultures
        1. Bacterial Cultures
          1. Archaeal Cultures
            1. Growth Requirements
              1. Metabolic Characteristics
              2. Eukaryotic Cell Cultures
                1. Yeast Cultures
                  1. Fungal Cultures
                    1. Animal Cell Cultures
                      1. Plant Cell Cultures
                      2. Structural and Functional Differences
                        1. Cell Wall Composition
                          1. Membrane Systems
                            1. Metabolic Pathways
                              1. Growth Rate Variations
                            2. Stoichiometry of Bioprocesses
                              1. Elemental Balances
                                1. Carbon Balance
                                  1. Nitrogen Balance
                                    1. Oxygen Balance
                                      1. Hydrogen Balance
                                        1. Phosphorus Balance
                                        2. Growth Stoichiometry
                                          1. Biomass Composition
                                            1. Substrate Consumption
                                              1. Product Formation
                                                1. Byproduct Generation
                                                2. Yield Coefficients
                                                  1. Biomass Yield on Substrate
                                                    1. Product Yield on Substrate
                                                      1. Product Yield on Biomass
                                                        1. Maintenance Coefficient
                                                        2. Respiratory Quotient
                                                          1. Definition and Calculation
                                                            1. Aerobic Metabolism
                                                              1. Anaerobic Metabolism
                                                                1. Mixed Metabolism
                                                              2. Kinetics of Cell Growth
                                                                1. Batch Growth Kinetics
                                                                  1. Lag Phase Characteristics
                                                                    1. Adaptation Mechanisms
                                                                      1. Duration Factors
                                                                      2. Exponential Growth Phase
                                                                        1. Maximum Specific Growth Rate
                                                                          1. Doubling Time
                                                                            1. Growth Rate Constants
                                                                            2. Stationary Phase
                                                                              1. Nutrient Limitation
                                                                                1. Product Accumulation
                                                                                  1. Growth Cessation
                                                                                  2. Death Phase
                                                                                    1. Cell Lysis Mechanisms
                                                                                      1. Decay Constants
                                                                                    2. Growth Models
                                                                                      1. Monod Kinetics
                                                                                        1. Monod Equation
                                                                                          1. Saturation Constant
                                                                                            1. Maximum Growth Rate
                                                                                              1. Model Limitations
                                                                                              2. Substrate Inhibition Models
                                                                                                1. Andrews Model
                                                                                                  1. Haldane Model
                                                                                                    1. Critical Substrate Concentrations
                                                                                                    2. Product Inhibition Models
                                                                                                      1. Linear Inhibition
                                                                                                        1. Non-competitive Inhibition
                                                                                                          1. Competitive Inhibition
                                                                                                        2. Product Formation Kinetics
                                                                                                          1. Growth-Associated Products
                                                                                                            1. Non-Growth-Associated Products
                                                                                                              1. Mixed Growth-Product Formation
                                                                                                                1. Luedeking-Piret Model
                                                                                                              2. Environmental Factors Affecting Growth
                                                                                                                1. Temperature Effects
                                                                                                                  1. Optimal Temperature Range
                                                                                                                    1. Temperature Coefficient
                                                                                                                      1. Heat Shock Response
                                                                                                                        1. Cold Shock Response
                                                                                                                        2. pH Effects
                                                                                                                          1. Optimal pH Range
                                                                                                                            1. pH Tolerance Limits
                                                                                                                              1. Buffering Systems
                                                                                                                                1. pH Control Strategies
                                                                                                                                2. Water Activity
                                                                                                                                  1. Definition and Measurement
                                                                                                                                    1. Osmotic Stress Response
                                                                                                                                      1. Compatible Solutes
                                                                                                                                        1. Control Methods
                                                                                                                                        2. Oxygen Requirements
                                                                                                                                          1. Aerobic Growth
                                                                                                                                            1. Anaerobic Growth
                                                                                                                                              1. Facultative Growth
                                                                                                                                                1. Microaerobic Conditions
                                                                                                                                                2. Nutrient Requirements
                                                                                                                                                  1. Macronutrients
                                                                                                                                                    1. Micronutrients
                                                                                                                                                      1. Growth Factors
                                                                                                                                                        1. Nutrient Limitation Effects

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                                                                                                                                                    1. Introduction to Bioprocess Engineering and Bioreactors

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                                                                                                                                                    3. Mass Transfer in Bioreactors