Virology

10.

Antiviral Therapy

10.1.

Principles of Antiviral Chemotherapy

10.1.1.

Selective Toxicity

10.1.2.

Therapeutic Index

10.1.3.

Drug Development Process

10.2.

Targets for Antiviral Drugs

10.2.1.

Viral Entry Inhibitors

10.2.2.

Uncoating Inhibitors

10.2.3.

Polymerase Inhibitors

10.2.4.

Protease Inhibitors

10.2.5.

Integrase Inhibitors

10.2.6.

Neuraminidase Inhibitors

10.2.7.

Maturation Inhibitors

10.3.

Antiviral Drug Resistance

10.3.1.

Mechanisms of Resistance

10.3.1.1.

Mutation in Drug Targets

10.3.1.2.

10.3.2.

Monitoring Resistance

10.3.3.

Combination Therapy

10.3.4.

Strategies to Prevent Resistance

10.4.

Side Effects and Toxicity of Antivirals

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11. Specialized Topics in Virology